Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/101288
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Type: | Journal article |
Title: | Comorbid externalising behaviour in AD/HD: evidence for a distinct pathological entity in adolescence |
Author: | Perera, S. Crewther, D. Croft, R. Keage, H. Hermens, D. Clark, C. |
Citation: | PLoS One, 2012; 7(9):e41407-1-e41407-12 |
Publisher: | Public Library of Science |
Issue Date: | 2012 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Scott, J. |
Statement of Responsibility: | Sharnel Perera, David Crewther, Rodney Croft, Hannah Keage, Daniel Hermens, C. Richard Clark |
Abstract: | While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD) have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the greater than 80% prevalence of comorbidity under the DSM-IV-TR diagnostic definitions. Here we investigate the event related potential (ERP) and psychometric profiles of Controls, AD/HD, and comorbid AD/HD (particularly AD/HD+ODD/CD) groups on six neurocognitive tasks thought to probe the constructs of selective and sustained attention, response inhibition and executive function. Data from 29 parameters extracted from a child group (age range 6 to 12; 52 Controls and 64 AD/HD) and from an adolescent group (age range 13 to 17; 79 Controls and 88 AD/HD) were reduced via a Principal Components Analysis, the 6 significant eigenvectors then used as determinants of cluster membership via a Two-Step Cluster Analysis. Two clusters were found in the analysis of the adolescent age group--a cluster dominated by Control and AD/HD participants without comorbidity, while the second cluster was dominated by AD/HD participants with externalising comorbidity (largely oppositional defiant/conduct disorder ODD/CD). A similar segregation within the child age group was not found. Further analysis of these objectively determined clusters in terms of their clinical diagnoses indicates a significant effect of ODD/CD comorbidity on a concurrent AD/HD diagnosis. We conclude that comorbid externalising behaviour in AD/HD constitutes a distinct pathological entity in adolescence. |
Keywords: | Externalising behaviour; AD/HD |
Rights: | © 2012 Perera et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0041407 |
Grant ID: | http://purl.org/au-research/grants/arc/LP0349079 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0041407 |
Appears in Collections: | Aurora harvest 7 Psychology publications |
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hdl_101288.pdf | Published version | 486.4 kB | Adobe PDF | View/Open |
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