Adelaide Research & Scholarship
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https://hdl.handle.net/2440/10489
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| Type: | Journal article |
| Title: | Immunohistochemical labeling of normal melanocytes |
| Author: | Dean, N. Brennan, J. Haynes, J. Goddard, C. Cooter, R. |
| Citation: | Applied Immunohistochemistry and Molecular Morphology, 2002; 10(3):199-204 |
| Publisher: | Lippincott Williams & Wilkins |
| Issue Date: | 2002 |
| ISSN: | 1541-2016 1533-4058 |
| Abstract: | Comparison of seven antibodies for the demonstration of normal melanocytes in formalin-fixed, paraffin-embedded surgical discard skin showed that the monoclonal antibody Mel-5 (clone TA99) directed against pigment associated antigen was the most sensitive. Quantitative data were obtained for the sensitivity of the antibodies NKI/beteb, S100, T311, Melan A (clone A103), c-kit, and Mel-5 in parallel sections of human skin. An anticytokeratin antibody (CK34betaE12) was also used to stain basal keratinocytes and provide a negative image of the melanocytes present. Optimal conditions for the use of Mel-5 in paraffin sections of skin are described. |
| Keywords: | Keratinocytes Melanocytes Humans Vimentin Glycoproteins S100 Proteins Neoplasm Proteins Antibodies, Monoclonal Antigens, Neoplasm Immunohistochemistry Sensitivity and Specificity Female Proto-Oncogene Proteins c-kit Keratins Melanoma-Specific Antigens MART-1 Antigen |
| Description: | Copyright © 2002 Lippincott Williams & Wilkins, Inc. |
| DOI: | 10.1097/00022744-200209000-00002 |
| Published version: | http://journals.lww.com/appliedimmunohist/pages/articleviewer.aspx?year=2002&issue=09000&article=00002&type=abstract |
| Appears in Collections: | Aurora harvest 7 Surgery publications |
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