Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/105556
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Theses |
Title: | The effects of curcuminoids on musculoskeletal pain: a systematic review |
Author: | Gaffey, Andrew Benedict |
Issue Date: | 2017 |
School/Discipline: | Joanna Briggs Institute |
Abstract: | Musculoskeletal pain creates a serious burden on quality of life across the globe. Its management represents a significant economic cost and monopolizes the time and attention of practitioners involved in medicine and complementary health. Substantial numbers of people use nutraceuticals and traditional remedies to assist in musculoskeletal pain management and improvement of function. Curcuminoids are one group of nutraceuticals which are gaining in popularity and being used for treating musculoskeletal pain. Curcuminoids are extracted from turmeric, which itself is a traditional botanical remedy. The aim of this thesis was to assess the effects of the use of curcuminoids on musculoskeletal pain through a systematic review of the available evidence. A database search was conducted for studies that assessed the effects of use of curcuminoids by themselves or in combination with other materials on musculoskeletal pain of clinical or experimental origin. It included CINAHL, Embase Cochrane Central, Pubmed, Scopus, Psychinfo and Clinicaltrials.gov. Alternate, traditional medicine and complementary medicine databases including NCCAM and NICM were searched for additional studies. Locations for the search for unpublished studies included: Mednar, Proquest theses and dissertations, Grey Source, Index to Theses, and Trove (Theses). The reference lists of all identified reports and articles were searched for additional studies. Studies in English language with human subjects using any form of control including placebo, treatment as usual and before and after measurements were considered for inclusion in the review. No time limit was imposed on studies for inclusion in the systematic review. Methodological quality of included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklist, and research data was extracted using the JBI Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) data extraction instruments. Thirteen randomized controlled trials including 1101 participants were included in this review. The overall quality of included studies was variable. Treatment duration ranged from 10 days to 32 weeks in the studies and included different dosages and presentations of curcuminoids and differing comparators. A high level of heterogeneity between studies and characteristics precluded meta-analysis of findings; therefore, a narrative analysis was presented. The major finding from the review was that there is currently insufficient evidence to support the effectiveness of the use of curcuminoids in musculoskeletal pain states. Interpretation of this finding needs to be considered in the context of significant limitations imposed by the variable quality of relevant studies, small sample sizes and the small number of relevant studies available for examination. The systematic review found that in the studies examined, the frequency or severity of adverse events relating to the use of curcuminoids was not significantly different from placebo or other study comparators. The findings from the systematic review support the claims of safety in the literature. The absence of long-term follow-up across all studies means that comment on the long-term effect of and safety of the use of curcuminoids in musculoskeletal pain requires further clarifying research. |
Advisor: | Campbell, Jared Porritt, Kylie Amanda Slater, Helen |
Dissertation Note: | Thesis (M.Clin.Sc.) -- University of Adelaide, Joanna Briggs Institute, 2017. |
Keywords: | cucumin curcuminoids turmeric pain |
Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
DOI: | 10.4225/55/592e664cb9718 |
Appears in Collections: | Research Theses |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
01front.pdf | 406.77 kB | Adobe PDF | View/Open | |
02whole.pdf | 1.42 MB | Adobe PDF | View/Open | |
Permissions Restricted Access | Library staff access only | 245.72 kB | Adobe PDF | View/Open |
Restricted Restricted Access | Library staff access only | 1.42 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.