Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/105746
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Type: | Journal article |
Title: | Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits |
Author: | Justice, A. Winkler, T. Feitosa, M. Graff, M. Fisher, V. Young, K. Barata, L. Deng, X. Czajkowski, J. Hadley, D. Ngwa, J. Ahluwalia, T. Chu, A. Heard-Costa, N. Lim, E. Perez, J. Eicher, J. Kutalik, Z. Xue, L. Mahajan, A. et al. |
Citation: | Nature Communications, 2017; 8(1):14977-1-14977-19 |
Publisher: | Nature Publishing Group |
Issue Date: | 2017 |
ISSN: | 2041-1723 2041-1723 |
Statement of Responsibility: | Anne E. Justice, Thomas W. Winkler, Mary F. Feitosa, Misa Graff, Virginia A. Fisher … Lyle J Palmer … et al. |
Abstract: | Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution. |
Keywords: | Humans Obesity Genetic Predisposition to Disease Body Mass Index Waist-Hip Ratio Smoking Epistasis, Genetic Phenotype Polymorphism, Single Nucleotide Quantitative Trait Loci Adult Adiposity Body Fat Distribution Waist Circumference Genome-Wide Association Study |
Rights: | © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
DOI: | 10.1038/ncomms14977 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/241944 http://purl.org/au-research/grants/nhmrc/339462 http://purl.org/au-research/grants/nhmrc/389875 http://purl.org/au-research/grants/nhmrc/389891 http://purl.org/au-research/grants/nhmrc/389892 http://purl.org/au-research/grants/nhmrc/389927 http://purl.org/au-research/grants/nhmrc/389938 http://purl.org/au-research/grants/nhmrc/442915 http://purl.org/au-research/grants/nhmrc/442981 http://purl.org/au-research/grants/nhmrc/496739 http://purl.org/au-research/grants/nhmrc/552485 http://purl.org/au-research/grants/nhmrc/552498 |
Published version: | http://dx.doi.org/10.1038/ncomms14977 |
Appears in Collections: | Aurora harvest 8 Public Health publications |
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hdl_105746.pdf | Published version | 1.5 MB | Adobe PDF | View/Open |
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