Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/107161
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Type: | Journal article |
Title: | Relationship between vascular resistance and sympathetic nerve fiber density in arterial vessels in children with sleep disordered breathing |
Author: | Kontos, A. Lushington, K. Martin, J. Schwarz, Q. Green, R. Wabnitz, D. Xu, X. Sokoya, E. Willoughby, S. Baumert, M. Ferrante, A. La Forgia, M. Kennedy, D. |
Citation: | Journal of the American Heart Association, 2017; 6(7):e006137-1-e006137-11 |
Publisher: | American Heart Association |
Issue Date: | 2017 |
ISSN: | 2047-9980 2047-9980 |
Statement of Responsibility: | Anna Kontos, Kurt Lushington, James Martin, Quenten Schwarz, Ryan Green, Ben, David Wabnitz, Xiangjun Xu, Elke M. Sokoya, Scott Willoughby, Mathias Baumert, Antonio Ferrante, Melissa La Forgia, Declan Kennedy |
Abstract: | Sleep disordered breathing in children is associated with increased blood flow velocity and sympathetic overactivity. Sympathetic overactivity results in peripheral vasoconstriction and reduced systemic vascular compliance, which increases blood flow velocity during systole. Augmented blood flow velocity is recognized to promote vascular remodeling. Importantly, increased vascular sympathetic nerve fiber density and innervation in early life plays a key role in the development of early-onset hypertension in animal models. Examination of sympathetic nerve fiber density of the tonsillar arteries in children undergoing adenotonsillectomy for Sleep disordered breathing will address this question in humans.Thirteen children scheduled for adenotonsillectomy to treat sleep disordered breathing underwent pupillometry, polysomnography, flow-mediated dilation, resting brachial artery blood flow velocity (velocity time integral), and platelet aggregation. The dorsal lingual artery (tonsil) was stained and immunofluorescence techniques used to determine sympathetic nerve fiber density. Sympathetic nerve fiber density was correlated with increased resting velocity time integral (r=0.63; P<0.05) and a lower Neuronal Pupillary Index (r=-0.71, P<0.01), as well as a slower mean pupillary constriction velocity (mean, r=-0.64; P<0.05). A faster resting velocity time integral was associated with a slower peak pupillary constriction velocity (r=-0.77; P<0.01) and higher platelet aggregation to collagen antigen (r=0.64; P<0.05). Slower mean and peak pupillary constriction velocity were associated with higher platelet aggregation scores (P<0.05; P<0.01, respectively).These results indicate that sympathetic activity is associated with change in both the function and structure of systemic vasculature in children with sleep disordered breathing. |
Keywords: | arterial blood flow arterial stiffness autonomic function flow‐mediated dilatation pediatrics shear stress sleep disordered breathing sympathetic sympathetic nerve fibre density vasculature |
Rights: | © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1161/JAHA.117.006137 |
Published version: | http://dx.doi.org/10.1161/jaha.117.006137 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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hdl_107161.pdf | Published Version | 1.75 MB | Adobe PDF | View/Open |
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