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https://hdl.handle.net/2440/109156
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Type: | Journal article |
Title: | Solar insolation in springtime influences age of onset of bipolar I disorder |
Author: | Bauer, M. Glenn, T. Alda, M. Aleksandrovich, M. Andreassen, O. Angelopoulos, E. Ardau, R. Ayhan, Y. Baethge, C. Bharathram, S. Bauer, R. Baune, B. Becerra-Palars, C. Bellivier, F. Belmaker, R. Berk, M. Bersudsky, Y. Bicakci, S. Birabwa-Oketcho, H. Bjella, T. et al. |
Citation: | Acta Psychiatrica Scandinavica, 2017; 136(6):571-582 |
Publisher: | John Wiley & Sons |
Issue Date: | 2017 |
ISSN: | 0001-690X 1600-0447 |
Statement of Responsibility: | M. Bauer ... B. Baune ... et al. |
Abstract: | Objective: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder. Method: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density. Results: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001). Conclusion: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge. |
Keywords: | bipolar disorder circadian rhythm epidemiology solar insolation |
Description: | Accepted for publication June 16, 2017 |
Rights: | © 2017 John Wiley & Sons A/S |
DOI: | 10.1111/acps.12772 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1059660 |
Published version: | http://dx.doi.org/10.1111/acps.12772 |
Appears in Collections: | Aurora harvest 3 Medical Sciences publications |
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