Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/112155
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Type: | Journal article |
Title: | Age-specific gender differences in early mortality following ST-segment elevation myocardial infarction in China |
Author: | Zheng, X. Dreyer, R. Hu, S. Spatz, E. Masoudi, F. Spertus, J. Nasir, K. Li, X. Li, J. Wang, S. Krumholz, H. Jiang, L. |
Citation: | Heart, 2015; 101(5):349-355 |
Publisher: | BMJ Publishing Group |
Issue Date: | 2015 |
ISSN: | 1355-6037 1468-201X |
Statement of Responsibility: | Xin Zheng, Rachel P Dreyer, Shuang Hu, Erica S Spatz, Frederick A Masoudi, John A Spertus, Khurram Nasir, Xi Li, Jing Li, Sisi Wang, Harlan M Krumholz, Lixin Jiang, for the China PEACE Collaborative Group |
Abstract: | Objective: To assess whether younger, but not older, women in China have higher in-hospital mortality following ST-Segment Elevation Myocardial Infarction (STEMI) compared with men, and whether this relationship varied over the last decade or across rural/urban areas. Methods; We analysed a nationally representative sample of 11 986 patients with STEMI from 162 Chinese hospitals in 2001, 2006 and 2011, in the China PEACE-Retrospective AMI Study and compared in-hospital mortality between women and men with gender–age interactions in multivariable models. Results: The overall in-hospital mortality rate was higher in women compared with men (17.2% vs 9.1%, p<0.0001; unadjusted OR 2.07, 95% CI 1.85 to 2.33). The unadjusted OR for mortality in women, compared with men, was 2.20 (95% CI 1.59 to 3.04), 2.21 (95% CI 1.74 to 2.79), 1.37 (95% CI 1.15 to 1.65) and 1.25 (95% CI 0.97 to 1.63) for ages <60, 60–69, 70–79 and ≥80 years, respectively. After adjustment for patient characteristics, hospital characteristics and year of study, the OR for mortality comparing women with men was 1.69 (95% CI 1.01 to 2.83), 1.64 (95% CI 1.24 to 2.19), 1.15 (95% CI 0.90 to 1.46) and 0.82 (95% CI 0.60 to 1.11) for ages <60, 60–69, 70–79 and ≥80 years, respectively. The gender–age interaction for mortality was statistically significant (p=0.009), even after adjustment for a wide range of confounders, and did not vary over time or across rural/urban areas. Conclusions: Among a Chinese population with STEMI, gender differences in early mortality were age-dependent and greatest in the younger groups <70 years of age. |
Keywords: | Percutaneous Coronary Intervention |
Rights: | Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
DOI: | 10.1136/heartjnl-2014-306456 |
Published version: | http://dx.doi.org/10.1136/heartjnl-2014-306456 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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