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https://hdl.handle.net/2440/11383
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DC Field | Value | Language |
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dc.contributor.author | Gedeon, A. | - |
dc.contributor.author | Glass, I. | - |
dc.contributor.author | Connor, J. | - |
dc.contributor.author | Mulley, J. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | American Journal of Medical Genetics Part A, 1996; 64(1):121-124 | - |
dc.identifier.issn | 0148-7299 | - |
dc.identifier.issn | 1096-8628 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11383 | - |
dc.description.abstract | A large family with non-specific X-linked mental retardation (MRX) was first described in 1991 [Glass et al., 1991], with a suggestion of linkage to Xq26-27. The maximum lod score was 1.60 (theta = 0.10) with the F9 locus. The localisation of this MRX gene has now been established by linkage to microsatellite markers. Peak pairwise lod scores of 4.02 and 4.01 (theta = 0.00) were attained at the DXS1114 and DXS994 loci respectively. This MRX gene is now designated MRX27 and is localised to Xq24-26 by recombination events detected by DXS424 and DXS102. This regional localisation spans 26.2 cM on the genetic background map and defines another distinct MRX interval by linkage to a specific region of the X chromosome. | - |
dc.language.iso | en | - |
dc.publisher | WILEY-LISS | - |
dc.source.uri | http://dx.doi.org/10.1002/(sici)1096-8628(19960712)64:1%3C121::aid-ajmg20%3E3.0.co;2-o | - |
dc.subject | X Chromosome | - |
dc.subject | Humans | - |
dc.subject | Chromosome Mapping | - |
dc.subject | Pedigree | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Genetic Linkage | - |
dc.subject | Intellectual Disability | - |
dc.subject | Genetic Carrier Screening | - |
dc.title | Genetic localisation of MRX27 to Xq24-26 defines another discrete gene for non-specific X-linked mental retardation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/(SICI)1096-8628(19960712)64:1<121::AID-AJMG20>3.0.CO;2-O | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 7 Genetics publications |
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