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https://hdl.handle.net/2440/113886
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Type: | Journal article |
Title: | Discovery of a novel long terminal repeat (LTR2i-SS) in Sus Scrofa |
Author: | Lim, S. Kortschak, R. Adelson, D. |
Citation: | Animal Genetics, 2014; 45(3):367-372 |
Publisher: | Wiley |
Issue Date: | 2014 |
ISSN: | 0268-9146 1365-2052 |
Statement of Responsibility: | Sim L. Lim, R. Daniel Kortschak and David L. Adelson |
Abstract: | Long terminal repeat (LTR) retrotransposons are transposable elements flanked by 5'/3' LTRs. They have a structure similar to endogenous retroviruses, but they lack the envelope (env) gene making them non-infectious. Long terminal repeats are motif-rich sequences and can act as bidirectional promoters or enhancers to regulate or inactivate genes by insertion. In this study, we identified a new chimeric LTR subfamily, LTR2i_SS, in the pig genome. This chimeric LTR family appears to be the ancestral form of the previously described LTR2_SS family. LTR2_SS appears to have deleted ~300 bp of un-annotated, ancestral sequence from LTR2i_SS. We identified no functional provirus sequences for either of these LTR types. LTR2i_SS sequences have been exapted into the untranslated regions of two protein-coding gene mRNAs. Both of these genes lie within previously mapped pig quantitative trait loci. |
Keywords: | Exaptation; long terminal repeat; repetitive elements; retrotransposon; retrovirus |
Rights: | © 2014 Stichting International Foundation for Animal Genetics |
DOI: | 10.1111/age.12138 |
Published version: | http://dx.doi.org/10.1111/age.12138 |
Appears in Collections: | Aurora harvest 8 Genetics publications |
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