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https://hdl.handle.net/2440/114191
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Type: | Journal article |
Title: | Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin |
Author: | Mousa, A. Abell, S.K. Shorakae, S. Harrison, C.L. Naderpoor, N. Hiam, D. Moreno-Asso, A. Stepto, N.K. Teede, H.J. de Courten, B. |
Citation: | Molecular Nutrition and Food Research, 2017; 61(11):1700488-1-1700488-11 |
Publisher: | Wiley |
Issue Date: | 2017 |
ISSN: | 1613-4125 1613-4133 |
Statement of Responsibility: | Aya Mousa, Sally K Abell, Soulmaz Shorakae, Cheryce L Harrison, Negar Naderpoor, Danielle Hiam, Alba Moreno-Asso, Nigel K Stepto, Helena J Teede and Barbora de Courten |
Abstract: | Scope: Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between vitamin D and inflammation, particularly adipokines, remains unexplored in pregnancy. Methods and results: In 102 overweight or obese pregnant women at high-risk of gestational diabetes mellitus (GDM), we investigated relationships between maternal 25-hydroxyvitamin D (25(OH)D) concentrations at 12–15 wk gestation (baseline) and serum lipids, inflammatory markers, novel adipokines (omentin-1, visfatin, high molecular weight (HMW) adiponectin), and subsequent pregnancy outcomes (GDM, preeclampsia, preterm birth [PTB]). After adjustment for maternal factors (age, BMI, parity, ethnicity, and smoking status), baseline 25(OH)D concentrations were inversely associated with total cholesterol and triglycerides, and positively associated with HMW-adiponectin. Higher baseline 25(OH)D concentrations were associated with decreased fasting and 1-h post-OGTT glucose and reduced risk of GDM at 26–28 wk, as well as with longer gestation and reduced risk of PTB upon additional adjustment for caesarean section. Adding HMW-adiponectin to the multivariable models attenuated most associations, and HMW-adiponectin was a significant predictor in the models. Conclusion: Our findings suggest that lower maternal 25(OH)D concentrations in overweight/ obese pregnant women at high-risk of GDM are associated with increased cardiometabolic risks during pregnancy and adverse pregnancy outcomes, and that these associations may be mediated by HMW-adiponectin. |
Keywords: | Adipokines; cardiometabolic risk factors; gestational diabetes mellitus; pregnancy; vitamin D |
Rights: | © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
DOI: | 10.1002/mnfr.201700488 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1002/mnfr.201700488 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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