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https://hdl.handle.net/2440/11580
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Type: | Journal article |
Title: | Interleukin-5 transgenic mice show enhanced resistance to primary infections with Nippostrongylus brasiliensis but not primary infections with Toxacara caris |
Author: | Dent, L. Daly, C. Mayrhofer, G. Zimmerman, T. Hallett, A. Bignold, L. Creaney, J. Parsons, J. |
Citation: | Infection and Immunity, 1999; 67(2):989-993 |
Publisher: | American Society for Microbiology |
Issue Date: | 1999 |
ISSN: | 0019-9567 1098-5522 |
Editor: | Mansfield, J.M. |
Statement of Responsibility: | Lindsay A. Dent, Christine M. Daly, Graham Mayrhofer, Trudy Zimmerman, Ann Hallett, Leon P. Bignold, Jenette Creaney, and Jim C. Parsons |
Abstract: | In this study, interleukin-5 (IL-5) transgenic mice with lifelong eosinophilia were assessed for resistance to primary infections with two tissue-invading nematodes, Nippostrongylus brasiliensisand Toxocara canis. Relative to nontransgenic littermates, three lines of IL-5 transgenic mice with varying degrees of eosinophilia all displayed enhanced resistance to N. brasiliensis. Although the timing of final worm expulsion was similar in transgenic and nontransgenic hosts, intestinal worms in transgenic mice were fewer in number throughout infection, failed to increase in size over the course of the infection, and were much less fecund. In contrast, T. canis larvae were recovered in similar numbers from tissues of transgenic mice with “low” or “high” eosinophilia and from nontransgenic mice. These results and other data suggest that eosinophils can contribute to host resistance to some parasite species. Parasite transit time through the host may correlate with relative sensitivity to eosinophils. |
Keywords: | Intestine, Small Ovum Animals Mice, Inbred CBA Mice, Transgenic Mice Toxocara canis Nippostrongylus Toxocariasis Strongylida Infections Eosinophilia Interleukin-5 Female Male Immunity, Innate |
Rights: | Copyright © 1999 American Society for Microbiology |
DOI: | 10.1128/iai.67.2.989-993.1999 |
Published version: | http://dx.doi.org/10.1128/iai.67.2.989-993.1999 |
Appears in Collections: | Aurora harvest 7 Microbiology and Immunology publications |
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