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https://hdl.handle.net/2440/11592
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Type: | Journal article |
Title: | Induction of T cell responses to the invariant chain derived peptide CLIP in mice immunized with the group 1 allergen of house dust mite |
Author: | Kristensen, N. Hoyne, G. Hayball, J. Hetzel, C. Bourne, T. Lamb, J. |
Citation: | International Immunology, 1996; 8(7):1091-1098 |
Publisher: | OXFORD UNIV PRESS UNITED KINGDOM |
Issue Date: | 1996 |
ISSN: | 0953-8178 1460-2377 |
Statement of Responsibility: | Nanna M. Kristensen, Gerard F. Hoyne, John D. Hayball, Charlotte Hetzel, Timothy Bourne and Jonathan R. Lamb |
Abstract: | In this study we demonstrate that immunization of H-2(b) mice with the allergen Der p 1 induces MHC class II restricted T cells that proliferate to residues 15-29 of Der p 1 (p15-29) and to the murine MHC class II-associated invariant chain derived peptide (CLIP). T cells from naive H-2(b) mice and those immunized with murine CLIP fail to respond to either CLIP or p15-29. T cell lines and clones reactive with p15-29 strongly proliferate in response to splenic antigen-presenting cells (APC) from normal H-2(b) mice but show reduced proliferation to APC from invariant chain deficient mice. Furthermore, T cells isolated from Der p 1 primed mice and expanded on H-2(b) spleen cells in the absence of the p15-29 epitope retained specificity for both p15-29 and CLIP, suggesting that naturally presented self components can act as mimetic peptides and may maintain T cell memory to foreign antigens. |
Keywords: | T-Lymphocytes Cells, Cultured Animals Mice, Inbred C57BL Humans Mice Mites Glycoproteins Antigens, CD Antigens, Differentiation, B-Lymphocyte Allergens Antigens, Dermatophagoides H-2 Antigens Histocompatibility Antigens Class II Vaccination Lymphocyte Activation Cross Reactions Amino Acid Sequence Sequence Homology, Amino Acid Molecular Sequence Data Female |
DOI: | 10.1093/intimm/8.7.1091 |
Published version: | http://dx.doi.org/10.1093/intimm/8.7.1091 |
Appears in Collections: | Aurora harvest 2 Microbiology and Immunology publications |
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