Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/11621
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Carr, J. | - |
dc.contributor.author | Ramshaw, H. | - |
dc.contributor.author | Li, P. | - |
dc.contributor.author | Burrell, C. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Journal of General Virology, 1998; 79(1):71-75 | - |
dc.identifier.issn | 0022-1317 | - |
dc.identifier.issn | 1465-2099 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11621 | - |
dc.description.abstract | Highly purified (>98%) CD34+ cells directly after isolation (D0) or 2 weeks in culture (D14) were CD4+ and contained mRNA for the T-tropic HIV co-receptor, CXCR-4, and minor co-receptor, CCR-2B. D14 but not D0 cells were RT-PCR positive for mRNA for the major M-tropic human immunodeficiency virus (HIV) co-receptor, CCR-5, and potential co-receptor, CCR-1. D14 and D0 cells were susceptible to T- (HXB2) and M-tropic HIV (Bal), showing greater virus production with Bal than HXB2, and with higher virus production levels in D14 compared to D0 cells. Seven days post-infection of D0 cells Bal DNA was present in CD14bright and CD14- fractions, suggesting D0 infection of diverse progenitor types. HXB2 DNA was detected in CD14bright cells alone indicating D0 infection of monocyte progenitors only. It is concluded that CD34+ cells and cultured derivatives are susceptible to M- and T-tropic HIV and this correlates in part with co-receptor expression at the mRNA level. | - |
dc.language.iso | en | - |
dc.publisher | SOC GENERAL MICROBIOLOGY | - |
dc.source.uri | http://dx.doi.org/10.1099/0022-1317-79-1-71 | - |
dc.subject | Hematopoietic Stem Cells | - |
dc.subject | Humans | - |
dc.subject | HIV | - |
dc.subject | Receptors, Chemokine | - |
dc.subject | Receptors, CCR5 | - |
dc.subject | Receptors, CXCR4 | - |
dc.subject | Receptors, Cytokine | - |
dc.subject | Receptors, HIV | - |
dc.subject | Gene Products, gag | - |
dc.subject | HIV Core Protein p24 | - |
dc.subject | DNA, Viral | - |
dc.subject | RNA, Messenger | - |
dc.subject | Antigens, CD | - |
dc.subject | Antigens, CD34 | - |
dc.subject | Receptors, CCR1 | - |
dc.subject | Receptors, CCR2 | - |
dc.subject | CD4 Antigens | - |
dc.title | CD34+ cells and their derivatives contain mRNA for CD4 and human immunodeficiency virus (HIV) co-receptors and are susceptible to infection with M- and T-tropic HIV. | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1099/0022-1317-79-1-71 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ramshaw, H. [0000-0001-9909-282X] | - |
dc.identifier.orcid | Burrell, C. [0000-0002-4020-349X] | - |
Appears in Collections: | Aurora harvest 2 Microbiology and Immunology publications |
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