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https://hdl.handle.net/2440/117032
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Type: | Journal article |
Title: | Liver resection for colorectal cancer metastases: a comparison of outcomes over time in South Australia |
Author: | Sultana, A. Meng, R. Piantadosi, C. Brooke-Smith, M. Chen, J. Dolan, P. Maddern, G. Price, T. Padbury, R. |
Citation: | Hepato Pancreato Biliary, 2018; 20(4):340-346 |
Publisher: | Elsevier |
Issue Date: | 2018 |
ISSN: | 1365-182X 1477-2574 |
Statement of Responsibility: | Asma Sultana, Rosie Meng, Cynthia Piantadosi, Mark Brooke-Smith, John Chen, Paul Dolan, Guy Maddern, Timothy Price, Robert Padbury |
Abstract: | Background: The aim of the current study was to assess outcomes following liver resection in metastatic CRC (mCRC) in South Australia across two study periods (pre-2006 versus post-2006). Methods: The South Australian (SA) Clinical Registry for mCRC maintains data prospectively on all patients in SA with mCRC diagnosed from 01 February 2006. This data was linked with a prospectively collated database on liver resections for mCRC from 01/01/1992 to 01/02/2006. The primary end point was overall survival. Results: 757 patients underwent liver resection for mCRC. Liver resection was performed on 286 patients pre-2006 and 471 patients post-2006. The median age of the study population was 62 years, and this was similar across both eras. Overall survival was significantly better in the post-2006 era (hazard ratio HR = 0.45, p = 0.001). Complications (59% pre-2006 versus 23% post-2006) and transfusion rates (34% pre-2006 versus 2% post-2006) were significantly higher in the pre-2006 era. Repeat liver resection rates were significantly higher in the post-2006 era (1% pre-2006 versus 10% post-2006). Conclusions: Outcomes following liver resection for mCRC have improved over time, with significantly better overall survival in the post-2006 era compared to pre-2006. |
Keywords: | Humans Colorectal Neoplasms Liver Neoplasms Treatment Outcome Hepatectomy Risk Factors Time Factors Databases, Factual Middle Aged South Australia Female Male |
Rights: | Crown Copyright © 2017 Published by Elsevier Ltd on behalf of International Hepato-Pancreato-Biliary Association Inc. All rights reserved. |
DOI: | 10.1016/j.hpb.2017.10.005 |
Published version: | http://dx.doi.org/10.1016/j.hpb.2017.10.005 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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