Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/11771
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Heterogeneity of the properties of I-Na in epicardial and endocardial cells of rat ventricle |
Author: | Honen, B. Saint, D. |
Citation: | Clinical and Experimental Pharmacology and Physiology, 2002; 29(3):161-166 |
Publisher: | Blackwell Science Asia |
Issue Date: | 2002 |
ISSN: | 0305-1870 1440-1681 |
Statement of Responsibility: | Bonny N Honen and David A Saint |
Abstract: | 1. Ventricular INa heterogeneity was investigated in adult rat hearts. Differences in transient outward potassium current (Ito) were used to confirm isolation of subepicardial and subendocardial cells. Mean peak Ito was 6.0 ± 0.7 and 1.6 ± 0.45 pA/pF in epicardial and endocardial cells, respectively (P < < 0.01). 2. Maximum sodium conductance was smaller in subendocardial cells compared with subepicardial cells (2.39 ± 0.11 vs 2.78 ± 0.12 nS/pF, respectively; n = 17 for both; 0.01 < P < 0.05) and 50% activation occurred at a slightly more negative potential (–47.6 ± 0.8 vs –44.9 ± 0.9mV, respectively; n = 10 for both; 0.01 < P < 0.05). 3. The potential for 50% inactivation was not significantly different in subepicardial compared with subendocardial cells (72.2 ± 1.0 vs 72.8 ± 2.2mV, respectively; n = 17 for both; NS). 4. Persistent sodium current density appeared smaller in subendocardial (n = 19) compared with subepicardial (n = 11) cells (at a test potential of –25mV current, density was 0.118 ± 0.041 vs 0.144 ± 0.085 pA/pF, respectively), although this was not statistically significant due to large variability between cells. 5. Mathematical modelling of the cardiac action potential indicated that the combined effects of differences in current density and voltage dependence of sodium currents are unlikely to contribute to ventricular action potential heterogeneity between epicardial and endocardial cells. |
Keywords: | endocardial epicardial rat ventricle regional differences sodium current |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1046/j.1440-1681.2002.03620.x |
Published version: | http://www.blackwell-synergy.com/doi/abs/10.1046/j.1440-1681.2002.03620.x |
Appears in Collections: | Aurora harvest 2 Physiology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.