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https://hdl.handle.net/2440/11787
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dc.contributor.author | Cummins, A. | - |
dc.contributor.author | Thompson, F. | - |
dc.contributor.author | Butler, R. | - |
dc.contributor.author | Cassidy, J. | - |
dc.contributor.author | Gillis, D. | - |
dc.contributor.author | Lorenzetti, M. | - |
dc.contributor.author | Southcott, E. | - |
dc.contributor.author | Wilson, P. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Clinical Science, 2001; 100(4):379-386 | - |
dc.identifier.issn | 0143-5221 | - |
dc.identifier.issn | 1470-8736 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11787 | - |
dc.description.abstract | It is often difficult to assess small bowel recovery in adults with coeliac disease on a gluten-free diet (GFD). This prospective study compares changes in intestinal permeability with changes in intestinal biopsy at various intervals after commencing a GFD. Intestinal permeability was measured by lactulose/rhamnose absorption from 1 week to 24 months after commencing a GFD. Intestinal morphometry was measured by villus area, crypt length and mitotic count per crypt at diagnosis and after commencing a GFD. Median intestinal permeability values decreased from 0.47 (n = 35) at diagnosis to 0.25 (n = 17) after 1 week and to 0.16 (n = 18) after 2 months of a GFD. Rhamnose absorption improved significantly at an early stage, from 6.6% (untreated) to 15.4% at 3 months of a GFD, whereas the decrease in lactulose permeation took longer: from 3.4% (untreated) to 0.8% after 12 months of a GFD. Mean villus area (n = 29) was reduced to 16% of control values at diagnosis, and improved to a maximum of 48% after 6 months on a GFD, but did not change thereafter. Mean crypt length and mitotic count per crypt were increased by 222% and 356% respectively at diagnosis, and these parameters remained elevated at 172% and 216% above control values after 6 months of a GFD. We conclude that intestinal permeability improves within 2 months after starting a GFD, but that measurable intestinal biopsy improvement requires ingestion of a GFD for at least 3-6 months, and even then remains incomplete. | - |
dc.language.iso | en | - |
dc.publisher | Portland Press | - |
dc.source.uri | http://dx.doi.org/10.1042/cs1000379 | - |
dc.subject | Duodenum | - |
dc.subject | Humans | - |
dc.subject | Celiac Disease | - |
dc.subject | Rhamnose | - |
dc.subject | Lactulose | - |
dc.subject | Gliadin | - |
dc.subject | Autoantibodies | - |
dc.subject | Biopsy | - |
dc.subject | Treatment Outcome | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Prospective Studies | - |
dc.subject | Intestinal Absorption | - |
dc.subject | Permeability | - |
dc.subject | Time Factors | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Glutens | - |
dc.title | Improvement in intestinal permeability precedes morphometric recovery of the small intestine in coeliac disease | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1042/CS20000193 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Cummins, A. [0000-0003-3115-9498] | - |
Appears in Collections: | Aurora harvest 2 Physiology publications |
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