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https://hdl.handle.net/2440/121483
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Type: | Journal article |
Title: | Bioinspired core-shell nanoparticles for hydrophobic drug delivery |
Author: | Yang, G. Liu, Y. Wang, H. Wilson, R. Hui, Y. Yu, L. Wibowo, D. Zhang, C. Whittaker, A.K. Middelberg, A.P.J. Zhao, C.X. |
Citation: | Angewandte Chemie International Edition, 2019; 58(40):14357-14364 |
Publisher: | Wiley |
Issue Date: | 2019 |
ISSN: | 1433-7851 1521-3773 |
Statement of Responsibility: | Guangze Yang, Yun Liu, Haofei Wang, Russell Wilson, Yue Hui ... Anton P. J. Middelberg ... et al. |
Abstract: | A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10 % or even 1 %. Now, core-shell nanoparticles are fabricated having exceptionally high drug loading up to 65 % (drug weight/the total weight of drug-loaded nanoparticles) and high encapsulation efficiencies (>99 %) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug-core silica-shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, the high drug loading nanoparticles lead to better in vitro cytotoxic effects and in vivo suppression of tumor growth, highlighting the significance of using high drug-loading nanoparticles. |
Keywords: | biomimetic synthesis cancer drug delivery nanoparticles peptides |
Rights: | © 2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim |
DOI: | 10.1002/anie.201908357 |
Grant ID: | http://purl.org/au-research/grants/arc/DP150100798 http://purl.org/au-research/grants/arc/FT140100726 http://purl.org/au-research/grants/arc/CE140100036 |
Published version: | http://dx.doi.org/10.1002/anie.201908357 |
Appears in Collections: | Aurora harvest 8 Chemistry publications |
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