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https://hdl.handle.net/2440/121741
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Type: | Journal article |
Title: | Dietary zinc and the control of Streptococcus pneumoniae infection |
Author: | Eijkelkamp, B.A. Morey, J.R. Neville, S.L. Tan, A. Pederick, V.G. Cole, N. Singh, P.P. Ong, C.-L.Y. Gonzalez de Vega, R. Clases, D. Cunningham, B.A. Hughes, C.E. Comerford, I. Brazel, E.B. Whittall, J.J. Plumptre, C.D. McColl, S.R. Paton, J.C. McEwan, A.G. Doble, P.A. et al. |
Citation: | PLoS Pathogens, 2019; 15(8):1-26 |
Publisher: | PLOSE ONE |
Issue Date: | 2019 |
ISSN: | 1553-7366 1553-7374 |
Editor: | Orihuela, C.J. |
Statement of Responsibility: | Bart A. Eijkelkamp, Jacqueline R. Morey, Stephanie L. Neville, Aimee Tan, Victoria G. Pederick, Nerida Cole, Prashina P. Singh, Cheryl-Lynn Y. Ong, Raquel Gonzalez de Vega, David Clases, Bliss A. Cunningham, Catherine E. Hughes, Iain Comerford, Erin B. Brazel, Jonathan J. Whittall, Charles D. Plumptre, Shaun R. McColl, James C. Paton, Alastair G. McEwan, Philip A. Doble, Christopher A. McDevitt |
Abstract: | Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced. Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised. S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells. Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences. |
Keywords: | Animals Mice Streptococcus pneumoniae Pneumococcal Infections Lung Diseases Disease Models, Animal Zinc Virulence Dietary Supplements Female |
Rights: | © 2019 Eijkelkamp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.ppat.1007957 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1080784 http://purl.org/au-research/grants/nhmrc/1071659 http://purl.org/au-research/grants/nhmrc/1122582 http://purl.org/au-research/grants/nhmrc/1142695 http://purl.org/au-research/grants/arc/DP170100036 http://purl.org/au-research/grants/arc/FT170100006 http://purl.org/au-research/grants/arc/DP190102361 http://purl.org/au-research/grants/arc/DP170102102 |
Published version: | http://dx.doi.org/10.1371/journal.ppat.1007957 |
Appears in Collections: | Aurora harvest 8 Microbiology and Immunology publications |
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