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https://hdl.handle.net/2440/121904
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Type: | Journal article |
Title: | A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo |
Author: | Potts, K.S. Sargeant, T.J. Markham, J.F. Shi, W. Biben, C. Josefsson, E.C. Whitehead, L.W. Rogers, K.L. Liakhovitskaia, A. Smyth, G.K. Kile, B.T. Medvinsky, A. Alexander, W.S. Hilton, D.J. Taoudi, S. |
Citation: | Blood, 2014; 124(17):2725-2729 |
Publisher: | American Society of Hematology |
Issue Date: | 2014 |
ISSN: | 0006-4971 1528-0020 |
Statement of Responsibility: | Kathryn S. Potts, Tobias J. Sargeant, John F. Markham, Wei Shi, Christine Biben ... Benjamin T. Kile ... et al. |
Abstract: | In this study, we test the assumption that the hematopoietic progenitor/colony-forming cells of the embryonic yolk sac (YS), which are endowed with megakaryocytic potential, differentiate into the first platelet-forming cells in vivo. We demonstrate that from embryonic day (E) 8.5 all megakaryocyte (MK) colony-forming cells belong to the conventional hematopoietic progenitor cell (HPC) compartment. Although these cells are indeed capable of generating polyploid MKs, they are not the source of the first platelet-forming cells. We show that proplatelet formation first occurs in a unique and previously unrecognized lineage of diploid platelet-forming cells, which develop within the YS in parallel to HPCs but can be specified in the E8.5 Runx1-null embryo despite the absence of the progenitor cell lineage. |
Keywords: | Megakaryocytes |
Rights: | © 2014 by The American Society of Hematology. |
DOI: | 10.1182/blood-2014-02-559468 |
Grant ID: | http://purl.org/au-research/grants/arc/1016647 http://purl.org/au-research/grants/nhmrc/361646 |
Published version: | http://dx.doi.org/10.1182/blood-2014-02-559468 |
Appears in Collections: | Aurora harvest 4 Medical Sciences publications |
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