Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/123704
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Effect of angiotensin II receptor blocker and salt supplementation on short-term blood pressure variability in type 2 diabetes |
Author: | Chen, A.X. Moran, J.L. Libianto, R. Baqar, S. O Callaghan, C. MacIsaac, R.J. Jerums, G. Ekinci, E.I. |
Citation: | Journal of Human Hypertension, 2019; 34(2):143-150 |
Publisher: | Springer Nature |
Issue Date: | 2019 |
ISSN: | 0950-9240 1476-5527 |
Statement of Responsibility: | Angela X. Chen, John L. Moran, Renata Libianto, Sara Baqar, Christopher O'Callaghan, Richard J. MacIsaac, George Jerums, Elif I. Ekinci |
Abstract: | High blood pressure variability (BPV) has been associated with increased cardiovascular (CV) risk. The effect of dietary salt and renin-angiotensin-aldosterone system (RAAS) activity on short-term BPV in type 2 diabetes mellitus (T2DM) is not well characterised. We aimed to determine the effect of dietary salt (sodium chloride, NaCl) supplementation on 24-h mean arterial BPV (24hBPV) during angiotensin II receptor blocker (telmisartan) use and to evaluate the effects of age, sex, plasma renin activity (PRA) and serum aldosterone on 24hBPV. In a randomised, double-blind, crossover study, patients with T2DM (n = 28), treated with telmisartan received NaCl (100 mmol/24 h) or placebo capsules during 2 weeks of telmisartan. Following a 6-week washout, the protocol was repeated in reverse. 24hBPV was evaluated as a co-efficient of variation [CV (%) = mean/standard deviation] × 100). Twenty-four hour urinary sodium excretion, ambulatory BP and biochemical tests were performed at each phase. Results were analysed using a linear mixed model to generate predicted values for 24hBPV. Predicted 24hBPV was higher with telmisartan vs baseline (p = 0.01), with a trend towards reduced 24hBPV with salt (p = 0.052). Predicted 24hBPV was lower in females (p = 0.017), increasing age (p = 0.001) and increasing PRA (p = 0.011). In patients with T2DM, predicted 24hBPV increased from baseline with telmisartan, but there was no additional increase in predicted 24hBPV with salt supplementation. This suggests that in the short-term, salt supplementation has no apparent deleterious effects on 24hBPV. Long-term studies are required to evaluate the effect of 24hBPV on CV outcomes in patients with T2DM. |
Keywords: | Humans Hypertension Diabetes Mellitus, Type 2 Sodium Chloride Sodium Chloride, Dietary Aldosterone Renin Angiotensin II Cross-Over Studies Renin-Angiotensin System Blood Pressure Dietary Supplements Female Angiotensin Receptor Antagonists |
Rights: | © The Author(s), under exclusive licence to Springer Nature Limited 2019. |
DOI: | 10.1038/s41371-019-0238-3 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/466611 http://purl.org/au-research/grants/nhmrc/1054312 |
Published version: | http://dx.doi.org/10.1038/s41371-019-0238-3 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.