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https://hdl.handle.net/2440/129750
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Type: | Journal article |
Title: | Evaluating the effectiveness of the 4CMenB vaccine against invasive meningococcal disease and gonorrhoea in an infant, child and adolescent program: protocol |
Author: | Marshall, H.S. Andraweera, P.H. Wang, B. McMillan, M. Koehler, A.P. Lally, N. Almond, S. Denehy, E. A'Houre, M. Giles, L.C. Flood, L. |
Citation: | Human Vaccines and Immunotherapeutics, 2021; 17(5):1450-1454 |
Publisher: | Taylor & Francis |
Issue Date: | 2021 |
ISSN: | 2164-5515 2164-554X |
Statement of Responsibility: | Helen S. Marshall, Prabha H. Andraweera, Bing Wang, Mark McMillan, Ann P. Koehler, Noel Lally ... et al. |
Abstract: | Invasive meningococcal disease causes significant morbidity and mortality worldwide, with serogroup B being one of the predominant serogroups in Australia for many years. The South Australian (SA) State Government recently funded the introduction of a 4CMenB vaccination program for infants, children and adolescents. In addition to protecting against invasive meningococcal disease, emerging evidence suggests the 4CMenB vaccine may also be effective against gonorrhoea due to genetic similarities between Neisseria meningitidis and Neisseria gonorrhoeae. The proposed project aims to evaluate the effectiveness of the SA 4CMenB vaccination program against invasive meningococcal disease and gonorrhoea through a combination of observational studies using routine surveillance and research data. The main methodological approaches involve an interrupted time series regression model, screening, and case-control analyses with different sets of controls to estimate vaccine impact and effectiveness. These analyses are designed to minimize potential biases inherent in all observational studies and to provide critical data on the effectiveness of the 4CMenB vaccine against two diseases of major global public health concern. |
Keywords: | 4CMenB Vaccine gonorrhoea meningitis meningococcal disease |
Rights: | © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
DOI: | 10.1080/21645515.2020.1827614 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1155066 |
Published version: | http://dx.doi.org/10.1080/21645515.2020.1827614 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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