Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/130089
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Gastric emptying in health and type 2 diabetes: an evaluation using a 75g oral glucose drink |
Author: | Xie, C. Huang, W. Wang, X. Trahair, L.G. Pham, H.T. Marathe, C.S. Young, R.L. Jones, K.L. Horowitz, M. Rayner, C.K. Wu, T. |
Citation: | Diabetes Research and Clinical Practice, 2021; 171:1-8 |
Publisher: | Elsevier |
Issue Date: | 2021 |
ISSN: | 0168-8227 1872-8227 |
Statement of Responsibility: | Cong Xie, Weikun Huang, Xuyi Wang, Laurence G.Trahair, Hung T.Pham, Chinmay S.Marathe ... et al. |
Abstract: | Aim: Gastric emptying is a major determinant of the glycaemic response to carbohydrate and is frequently abnormal in type 2 diabetes (T2DM). There is little information about how chronic glycaemic control affects gastric emptying in T2DM. We evaluated gastric emptying of a 75 g glucose drink in community-based patients with T2DM of short duration with good or poor glycaemic control, and compared this to young and older controls. Methods: T2DM patients managed by diet and/or metformin, either well-controlled or poorly-controlled, together with young and age-matched older controls without diabetes, consumed a 75 g oral glucose drink containing 150 mg 13C-acetate for evaluation of gastric emptying (breath test) and blood glucose over 180 min. Results: The gastric half-emptying time (T50) was longer in the older than the young non-diabetic subjects (P = 0.041), but shorter in well-controlled T2DM patients than age-matched older controls (P = 0.043). The T50 in poorly-controlled T2DM patients was shorter than in older controls (P = 0.006), but similar to young non-diabetic subjects. Conclusions: Gastric emptying of a glucose drink is delayed with ageing, but more rapid in patients with T2DM of relatively short duration, regardless of their glycaemic status. These observations support interventions that slow gastric emptying to improve postprandial glycaemia in these patients with T2DM. |
Keywords: | Gastric emptying ageing glycaemic control postprandial glycaemia type 2 diabetes |
Rights: | © 2020 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.diabres.2020.108610 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1147333 http://purl.org/au-research/grants/nhmrc/1066835 http://purl.org/au-research/grants/nhmrc/1066815 http://purl.org/au-research/grants/nhmrc/627139 |
Published version: | http://dx.doi.org/10.1016/j.diabres.2020.108610 |
Appears in Collections: | Aurora harvest 8 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.