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https://hdl.handle.net/2440/131071
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Type: | Journal article |
Title: | Efficacy and safety of statins in ethnic differences: a lesson for application in Indigenous Australian patient care |
Author: | Gebremichael, L.G. Suppiah, V. Wiese, M.D. Mackenzie, L. Phillips, C. Williams, D.B. Roberts, M.S. |
Citation: | Pharmacogenomics, 2021; 22(9):553-571 |
Publisher: | Future Medicine |
Issue Date: | 2021 |
ISSN: | 1462-2416 1744-8042 |
Statement of Responsibility: | Lemlem G Gebremichael, Vijayaprakash Suppiah, Michael D Wiese, Lorraine Mackenzie, Craig Phillips, Desmond B Williams, Michael S Roberts |
Abstract: | Although statins are effective in treating high cholesterol, adverse effects do occur with their use. Efficacy and tolerability vary among statins in different ethnic groups. Indigenous Australians have a high risk for cardiovascular and kidney diseases. Prescribing statins to Indigenous Australians with multi-morbidity requires different strategies to increase efficacy and reduce their toxicity. Previous studies have reported that Indigenous Australians are more susceptible to severe statin-induced myopathies. However, there is a lack of evidence in the underlying genetic factors in this population. This review aims to identify: inter-ethnic differences in the efficacy and safety of statins; major contributing factors accounting for any identified differences; and provide an overview of statin-induced adverse effects in Indigenous Australians. |
Keywords: | Indigenous ethnic groups pharmacogenetics safety statin |
Rights: | © 2021 Future Medicine Ltd. |
DOI: | 10.2217/pgs-2020-0152 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1107356 |
Published version: | http://dx.doi.org/10.2217/pgs-2020-0152 |
Appears in Collections: | Aurora harvest 8 Biochemistry publications |
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