Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/131268
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Physiological functions of bacterial “multidrug” efflux pumps |
Author: | Henderson, P.J.F. Maher, C. Elbourne, L.D.H. Eijkelkamp, B.A. Paulsen, I.T. Hassan, K.A. |
Citation: | Chemical Reviews, 2021; 121(9):5417-5478 |
Publisher: | American Chemical Society |
Issue Date: | 2021 |
ISSN: | 0009-2665 1520-6890 |
Statement of Responsibility: | Peter J. F. Henderson, Claire Maher, Liam D. H. Elbourne, Bart A. Eijkelkamp, Ian T. Paulsen, and Karl A. Hassan |
Abstract: | Bacterial multidrug efflux pumps have come to prominence in human and veterinary pathogenesis because they help bacteria protect themselves against the antimicrobials used to overcome their infections. However, it is increasingly realized that many, probably most, such pumps have physiological roles that are distinct from protection of bacteria against antimicrobials administered by humans. Here we undertake a broad survey of the proteins involved, allied to detailed examples of their evolution, energetics, structures, chemical recognition, and molecular mechanisms, together with the experimental strategies that enable rapid and economical progress in understanding their true physiological roles. Once these roles are established, the knowledge can be harnessed to design more effective drugs, improve existing microbial production of drugs for clinical practice and of feedstocks for commercial exploitation, and even develop more sustainable biological processes that avoid, for example, utilization of petroleum. |
Keywords: | Animals Humans Bacteria Membrane Transport Proteins Anti-Bacterial Agents Drug Resistance, Microbial Bacterial Outer Membrane |
Rights: | © 2021 American Chemical Society |
DOI: | 10.1021/acs.chemrev.0c01226 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/GNT1060895 http://purl.org/au-research/grants/nhmrc/GNT1120298 http://purl.org/au-research/grants/arc/FT180100123 |
Published version: | http://dx.doi.org/10.1021/acs.chemrev.0c01226 |
Appears in Collections: | Aurora harvest 8 Chemistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.