Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/131949
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yan, J. | - |
dc.contributor.author | Marina, P.F. | - |
dc.contributor.author | Blencowe, A. | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Polymers, 2021; 13(9):1403-1-1403-11 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.issn | 2073-4360 | - |
dc.identifier.uri | http://hdl.handle.net/2440/131949 | - |
dc.description | Published: 26 April 2021 | - |
dc.description.abstract | Amino end-group functionalised polyglycols are important intermediates in the synthesis of sophisticated polymeric architectures and biomaterials. Herein, we report a facile strategy for the end-group conversion of hydroxyl-terminated polyglycols to amino-terminated polyglycols in high isolated yields and with excellent end-group fidelity. Following traditional conversion of polyglycol hydroxyl end-groups to azides via the corresponding mesylate, reduction with zinc in the presence of ammonium chloride afforded a range of amino end-group functionalised poly(ethylene glycol) and poly(propylene glycol) homopolymers and copolymers with isolated yields of 82-99% and end-group conversions of >99% as determined by NMR spectroscopy and MALDI ToF MS. Furthermore, this process is applicable to a sequential reagent addition approach without intermediate polymer isolation steps with only a slight reduction in yield and end-group conversion (95%). Importantly, a simple work-up procedure provides access to high purity polyglycols without contamination from other reagents. | - |
dc.description.statementofresponsibility | Jie Yan, Paula Facal Marina and Anton Blencowe | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.rights | Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | - |
dc.source.uri | http://dx.doi.org/10.3390/polym13091403 | - |
dc.subject | polyglycol | - |
dc.subject | amino end-group | - |
dc.subject | Zn-mediated reduction | - |
dc.subject | poly(ethylene glycol) | - |
dc.subject | end-group transformations | - |
dc.title | A facile strategy for the high yielding, quantitative conversion of polyglycol end-groups to amines | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.3390/polym13091403 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 4 Chemistry publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_131949.pdf | Published version | 1.15 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.