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https://hdl.handle.net/2440/132259
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Type: | Journal article |
Title: | Long-term effects of a preconception lifestyle intervention on cardiometabolic health of overweight and obese women |
Author: | Wekker, V. Huvinen, E. van Dammen, L. Rono, K. Painter, R.C. Zwinderman, A.H. van de Beek, C. Sarkola, T. Mol, B.W.J. Groen, H. Hoek, A. Koivusalo, S.B. Roseboom, T.J. Eriksson, J.G. |
Citation: | European Journal of Public Health, 2019; 29(2):308-314 |
Publisher: | Oxford University Press |
Issue Date: | 2019 |
ISSN: | 1101-1262 1464-360X |
Statement of Responsibility: | Vincent Wekker, Emilia Huvinen, Lotte van Dammen, Kristiina Rono, Rebecca C Painter, Aeilko H Zwinderman ... et al. |
Abstract: | BACKGROUND:The global prevalence of obesity in women keeps increasing. The preconception period may be a window of opportunity to improve lifestyle, reduce obesity and improve cardiometabolic health. This study assessed the effect of a preconception lifestyle intervention on long-term cardiometabolic health in two randomized controlled trials (RCTs). METHODS:Participants of the LIFEstyle and RADIEL preconception lifestyle intervention studies with a baseline body mass index (BMI) ≥29 kg/m2 were eligible for this follow-up study. Both studies randomized between a lifestyle intervention targeting physical activity, diet and behaviour modification or usual care. We assessed cardiometabolic health 6 years after randomization. RESULTS:In the LIFEstyle study (n = 111) and RADIEL study (n = 39), no statistically significant differences between the intervention and control groups were found for body composition, blood pressure, arterial stiffness, fasting glucose, homeostasis model assessment of insulin resistance, HbA1c, lipids and high sensitive C-reactive protein levels 6 years after randomization. Participants of the LIFEstyle study who successfully lost ≥5% bodyweight or reached a BMI <29 kg/m2 during the intervention (n = 22, [44%]) had lower weight (-8.1 kg; 99% CI [-16.6 to -0.9]), BMI (-3.3 kg/m2; [-6.5 to -0.8]), waist circumference (-8.2 cm; [-15.3 to -1.3]), fasting glucose (-0.5 mmol/L; [-1.1 to -0.0]), HbA1c (-4.1 mmol/mol; [-9.1 to -0.8]), and higher HDL-C (0.3 mmol/L; [0.1-0.5]) compared with controls. CONCLUSION:We found no evidence of improved cardiometabolic health 6 years after a preconception lifestyle intervention among overweight and obese women in two RCTs. Women who successfully lost weight during the intervention had better cardiometabolic health 6 years later, emphasizing the potential of successful preconception lifestyle improvement. |
Keywords: | Humans Obesity Blood Glucose Lipids Body Weights and Measures Body Mass Index Exercise Preconception Care Diet Health Behavior Life Style Blood Pressure Socioeconomic Factors Adolescent Adult Female Overweight Young Adult Motivational Interviewing |
Rights: | © The Author(s) 2018. Published by Oxford University Press on behalf of the European Public Health Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/ 4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1093/eurpub/cky222 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1082548 |
Published version: | http://dx.doi.org/10.1093/eurpub/cky222 |
Appears in Collections: | Public Health publications |
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