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https://hdl.handle.net/2440/132641
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dc.contributor.author | Liu, Y. | - |
dc.contributor.author | Yang, G. | - |
dc.contributor.author | Jin, S. | - |
dc.contributor.author | Zhang, R. | - |
dc.contributor.author | Chen, P. | - |
dc.contributor.author | Tengjisi, | - |
dc.contributor.author | Wang, L. | - |
dc.contributor.author | Chen, D. | - |
dc.contributor.author | Weitz, D.A. | - |
dc.contributor.author | Zhao, C.X. | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Angewandte Chemie International Edition, 2020; 59(45):20065-20074 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.issn | 1521-3773 | - |
dc.identifier.uri | https://hdl.handle.net/2440/132641 | - |
dc.description.abstract | Understanding drug-release kinetics is critical for the development of drug-loaded nanoparticles. We developed a J-aggregate-based Förster-resonance energy-transfer (FRET) method to investigate the release of novel high-drug-loading (50 wt %) nanoparticles in comparison with low-drug-loading (0.5 wt %) nanoparticles. Single-dye-loaded nanoparticles form J-aggregates because of the high dye-loading (50 wt %), resulting in a large red-shift (≈110 nm) in the fluorescence spectrum. Dual-dye-loaded nanoparticles with high dye-loading using FRET pairs exhibited not only FRET but also a J-aggregate red-shift (116 nm). Using this J-aggregate-based FRET method, dye-core-polymer-shell nanoparticles showed two release processes intracellularly: the dissolution of the dye aggregates into dye molecules and the release of the dye molecules from the polymer shell. Also, the high-dye-loading nanoparticles (50 wt %) exhibited a slow release kinetics in serum and relatively quick release in cells, demonstrating their great potential in drug delivery. | - |
dc.description.statementofresponsibility | Yun Liu, Guangze Yang, Song Jin, Run Zhang, Peng Chen, Tengjisi, Lianzhou Wang, Dong Chen, David A. Weitz, and Chun-Xia Zhao | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2020 Wiley-VCH GmbH | - |
dc.source.uri | http://dx.doi.org/10.1002/anie.202008018 | - |
dc.subject | drug release; FRET; J-aggregates; nanoparticles; polymers | - |
dc.subject.mesh | Polymers | - |
dc.subject.mesh | Drug Carriers | - |
dc.subject.mesh | Microscopy, Electron, Transmission | - |
dc.subject.mesh | Fluorescence Resonance Energy Transfer | - |
dc.subject.mesh | Nanoparticles | - |
dc.subject.mesh | Drug Liberation | - |
dc.title | J-Aggregate-Based FRET Monitoring of Drug Release from Polymer Nanoparticles with High Drug Loading | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/anie.202008018 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/FT140100726 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP200101238 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Liu, Y. [0000-0003-1320-139X] | - |
dc.identifier.orcid | Yang, G. [0000-0002-6194-1918] | - |
dc.identifier.orcid | Jin, S. [0000-0001-8721-6987] | - |
Appears in Collections: | Chemical Engineering publications |
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