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https://hdl.handle.net/2440/13292
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DC Field | Value | Language |
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dc.contributor.author | Wheeler, D. | - |
dc.contributor.author | Hope, R. | - |
dc.contributor.author | Cooper, S. | - |
dc.contributor.author | Dolman, G. | - |
dc.contributor.author | Webb, G. | - |
dc.contributor.author | Bottema, C. | - |
dc.contributor.author | Gooley, A. | - |
dc.contributor.author | Goodman, M. | - |
dc.contributor.author | Holland, R. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of USA, 2001; 98(3):1101-1106 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.issn | 1091-6490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/13292 | - |
dc.description | © 2001 National Academy of Sciences | - |
dc.description.abstract | Mammals possess multiple, closely linked β-globin genes that differ in the timing of their expression during development. These genes have been thought to be derived from a single ancestral gene, by duplication events that occurred after the separation of the mammals and birds. We report the isolation and characterization of an atypical β-like globin gene (ω-globin) in marsupials that appears to be more closely related to avian β-globin genes than to other mammalian β-globin genes, including those previously identified in marsupials. Phylogenetic analyses indicate that ω-globin evolved from an ancient gene duplication event that occurred before the divergence of mammals and birds. Furthermore, we show that ω-globin is unlinked to the previously characterized β-globin gene cluster of marsupials, making this the first report of an orphaned β-like globin gene expressed in a vertebrate. | - |
dc.description.statementofresponsibility | David Wheeler; Rory Hope; Steven J. B. Cooper; Gaynor Dolman; Graham C. Webb; Cynthia D. K. Bottema; Andrew A. Gooley; Morris Goodman and Robert A. B. Holland | - |
dc.language.iso | en | - |
dc.publisher | Natl Acad Sciences | - |
dc.source.uri | http://www.jstor.org/stable/3054828 | - |
dc.subject | Animals | - |
dc.subject | Mammals | - |
dc.subject | Marsupialia | - |
dc.subject | Humans | - |
dc.subject | Globins | - |
dc.subject | Cloning, Molecular | - |
dc.subject | Polymerase Chain Reaction | - |
dc.subject | Sequence Alignment | - |
dc.subject | Evolution, Molecular | - |
dc.subject | Phylogeny | - |
dc.subject | Gene Duplication | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Base Sequence | - |
dc.subject | Molecular Sequence Data | - |
dc.title | An orphaned mammalian b-globin gene of ancient evolutionary origin | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1073/pnas.98.3.1101 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Cooper, S. [0000-0002-7843-8438] | - |
dc.identifier.orcid | Dolman, G. [0000-0001-7611-6841] | - |
dc.identifier.orcid | Bottema, C. [0000-0001-6245-0099] | - |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 7 Environment Institute Leaders publications Environment Institute publications Molecular and Biomedical Science publications |
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