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https://hdl.handle.net/2440/134031
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dc.contributor.author | Xie, C. | - |
dc.contributor.author | Huang, W. | - |
dc.contributor.author | Watson, L.E. | - |
dc.contributor.author | Soenen, S. | - |
dc.contributor.author | Young, R.L. | - |
dc.contributor.author | Jones, K.L. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Rayner, C.K. | - |
dc.contributor.author | Wu, T. | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2022; 107(4):e1643-e1652 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 1945-7197 | - |
dc.identifier.uri | https://hdl.handle.net/2440/134031 | - |
dc.description | First Published Online: 13 November 2021 | - |
dc.description.abstract | Context Both gastric emptying and the secretion of glucagon-like peptide-1 (GLP-1) are major determinants of postprandial glycemia in health and type 2 diabetes (T2D). GLP-1 secretion after a meal is dependent on the entry of nutrients into the small intestine, which, in turn, slows gastric emptying. Objective To define the relationship between gastric emptying and the GLP-1 response to both oral and small intestinal nutrients in subjects with and without T2D. Methods We evaluated: (i) the relationship between gastric emptying (breath test) and postprandial GLP-1 levels after a mashed potato meal in 73 individuals with T2D; (ii) inter-individual variations in GLP-1 response to (a) intraduodenal glucose (4 kcal/min) during euglycemia and hyperglycemia in 11 healthy and 12 T2D, subjects, (b) intraduodenal fat (2 kcal/min) in 15 T2D subjects, and (c) intraduodenal protein (3 kcal/min) in 10 healthy subjects; and (iii) the relationship between gastric emptying (breath test) of 75 g oral glucose and the GLP-1 response to intraduodenal glucose (4 kcal/min) in 21 subjects (9 healthy, 12 T2D). Results The GLP-1 response to the mashed potato meal was unrelated to the gastric half-emptying time (T50). The GLP-1 responses to intraduodenal glucose, fat, and protein varied substantially between individuals, but intra-individual variation to glucose was modest. The T50 of oral glucose was related directly to the GLP-1 response to intraduodenal glucose (r = 0.65, P = 0.002). Conclusion In a given individual, gastric emptying is not a determinant of the postprandial GLP-1 response. However, the intrinsic gastric emptying rate is determined in part by the responsiveness of GLP-1 to intestinal nutrients. | - |
dc.description.statementofresponsibility | Cong Xie, Weikun Huang, Linda E Watson, Stijn Soenen, Richard L Young, Karen L Jones, Michael Horowitz, Christopher K. Rayner, and Tongzhi Wu | - |
dc.language.iso | en | - |
dc.publisher | The Endocrine Society | - |
dc.rights | © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1210/clinem/dgab828 | - |
dc.subject | gastric emptying; GLP-1; postprandial glucose metabolism; type 2 diabetes | - |
dc.title | Plasma GLP-1 response to oral and intraduodenal nutrients in health and type 2 diabetes - impact on gastric emptying | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1210/clinem/dgab828 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Xie, C. [0000-0002-0054-9269] | - |
dc.identifier.orcid | Huang, W. [0000-0001-9400-3840] | - |
dc.identifier.orcid | Soenen, S. [0000-0002-0196-128X] | - |
dc.identifier.orcid | Young, R.L. [0000-0001-5116-4951] [0009-0004-8274-9863] | - |
dc.identifier.orcid | Jones, K.L. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Rayner, C.K. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Wu, T. [0000-0003-1656-9210] | - |
Appears in Collections: | Medicine publications |
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