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https://hdl.handle.net/2440/134349
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Type: | Journal article |
Title: | Influence of nanoparticle mechanical property on protein corona formation |
Author: | Tengjisi, Hui, Y. Fan, Y. Zou, D. Talbo, G.H. Yang, G. Zhao, C.X. |
Citation: | Journal of Colloid and Interface Science, 2022; 606(2):1737-1744 |
Publisher: | Elsevier |
Issue Date: | 2022 |
ISSN: | 0021-9797 1095-7103 |
Statement of Responsibility: | Tengjisi, Yue Hui, Yuanyuan Fan, DaZou, Gert H.Talbo, Guangze Yang, Chun-Xia Zhao |
Abstract: | A protein corona forms around nanoparticles when they are intravenously injected into the bloodstream. The composition of the protein corona dictates the interactions between nanoparticles and the biological systems thus their immune evasion, blood circulation, and biodistribution. Here, we report for the first time the impact of nanoparticle stiffness on protein corona formation using a unique emulsion core silica shell nanocapsules library with a wide range of mechanical properties over four magnitudes (700 kPa to 10 GPa). The nanocapsules with different stiffness showed distinct proteomic fingerprints. The protein corona of the stiffest nanocapsules contained the highest amount of complement protein (Complement C3) and immunoglobulin proteins, which contributed to their high macrophage uptake, confirming the important role of nanocapsules stiffness in controlling the protein corona formation thus their in vitro and in vivo behaviors. |
Keywords: | Cell uptake Drug delivery Mechanical property Nanomedicine Nanoparticle Protein adsorption Protein corona Silica Stiffness |
Rights: | © 2021 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.jcis.2021.08.148 |
Grant ID: | http://purl.org/au-research/grants/arc/DP210103079 http://purl.org/au-research/grants/arc/DP200101238 http://purl.org/au-research/grants/arc/FT140100726 |
Published version: | http://dx.doi.org/10.1016/j.jcis.2021.08.148 |
Appears in Collections: | Chemical Engineering publications |
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