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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/135149
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dc.contributor.authorFoeng, J.-
dc.contributor.authorComerford, I.-
dc.contributor.authorMcColl, S.R.-
dc.date.issued2022-
dc.identifier.citationCell Reports Medicine, 2022; 3(3):100543-1-100543-15-
dc.identifier.issn2666-3791-
dc.identifier.issn2666-3791-
dc.identifier.urihttps://hdl.handle.net/2440/135149-
dc.description.abstractCAR-T cell therapy has been heralded as a breakthrough in the field of immunotherapy, but to date, this suc- cess has been limited to hematological malignancies. By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis and overcome a major hurdle in generating effective CAR-T cell responses to solid cancers.-
dc.description.statementofresponsibilityJade Foeng, Iain Comerford, and Shaun R. McColl-
dc.language.isoen-
dc.publisherElsevier BV-
dc.rights© 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).-
dc.source.urihttp://dx.doi.org/10.1016/j.xcrm.2022.100543-
dc.subjectT-Lymphocytes-
dc.subjectHumans-
dc.subjectNeoplasms-
dc.subjectReceptors, Antigen, T-Cell-
dc.subjectChemokines-
dc.subjectImmunotherapy, Adoptive-
dc.subjectTumor Microenvironment-
dc.subject.meshT-Lymphocytes-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshReceptors, Antigen, T-Cell-
dc.subject.meshChemokines-
dc.subject.meshImmunotherapy, Adoptive-
dc.subject.meshTumor Microenvironment-
dc.titleHarnessing the chemokine system to home CAR-T cells into solid tumors-
dc.typeJournal article-
dc.identifier.doi10.1016/j.xcrm.2022.100543-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1030247-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1105312-
pubs.publication-statusPublished-
dc.identifier.orcidMcColl, S.R. [0000-0003-0949-4660]-
Appears in Collections:Microbiology and Immunology publications

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