Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/138172
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Type: | Journal article |
Title: | Identifying women who may benefit from higher dose omega-3 supplementation during pregnancy to reduce their risk of prematurity: exploratory analyses from the ORIP trial. |
Author: | Yelland, L.N. Sullivan, T.R. Gibson, R.A. Simmonds, L.A. Thakkar, S.K. Huang, F. Devaraj, S. Best, K.P. Zolezzi, I.S. Makrides, M. |
Citation: | BMJ Open, 2023; 13(4):e070220-e070220 |
Publisher: | BMJ |
Issue Date: | 2023 |
ISSN: | 2044-6055 2044-6055 |
Statement of Responsibility: | Lisa N Yelland, Thomas R Sullivan, Robert A Gibson, Lucy A Simmonds, Sagar K Thakkar, Fang Huang, Surabhi Devaraj, Karen P Best, Irma Silva Zolezzi, Maria Makrides |
Abstract: | OBJECTIVES: The risk factors for prematurity are multifactorial and include low omega-3 status. Omega-3 supplementation in pregnancy has been found to reduce prematurity risk, particularly among women with low omega-3 levels. This study aimed to identify maternal characteristics that predict whether women with a singleton pregnancy will benefit from omega-3 supplementation to reduce their risk of prematurity. DESIGN: Exploratory analyses of a multicentre, double-blind randomised trial. SETTING: 6 tertiary care centres in four states in Australia. PARTICIPANTS: 5328 singleton pregnancies in 5305 women recruited before 20 weeks of gestation. INTERVENTIONS: Fish oil capsules containing 900 mg omega-3 long-chain polyunsaturated fatty acids per day versus vegetable oil capsules consumed from enrolment until 34 weeks' gestation. OUTCOME MEASURES: Early preterm birth (EPTB, <34 weeks' gestation) and preterm birth (PTB, <37 weeks' gestation) analysed using logistic regression models with interactions between treatment group and a range of maternal biological, clinical and demographic characteristics. RESULTS: Omega-3 supplementation reduced the odds of EPTB for women with low total omega-3 status in early pregnancy (OR=0.30, 95% CI 0.10-0.93). No additional maternal characteristics influenced whether omega-3 supplementation reduced the odds of EPTB. For PTB, women were more likely to benefit from omega-3 supplementation if they were multiparous (OR=0.65, 95% CI 0.49-0.87) or avoided alcohol in the lead up to pregnancy (OR=0.62, 95% CI 0.45-0.86). CONCLUSIONS: Our results support previous findings that women with low total omega-3 levels in early pregnancy are most likely to benefit from taking omega-3 supplements to reduce their risk of EPTB. Understanding how other maternal characteristics influence the effectiveness of omega-3 supplementation on reducing PTB requires further investigation. TRIAL REGISTRATION NUMBER: ACTRN12613001142729. |
Keywords: | NEONATOLOGY NUTRITION & DIETETICS OBSTETRICS PUBLIC HEALTH |
Rights: | © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
DOI: | 10.1136/bmjopen-2022-070220 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/APP1135155 |
Published version: | http://dx.doi.org/10.1136/bmjopen-2022-070220 |
Appears in Collections: | Public Health publications |
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hdl_138172.pdf | Published version | 396.07 kB | Adobe PDF | View/Open |
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