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https://hdl.handle.net/2440/138433
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Type: | Journal article |
Title: | Effects of two different dietary patterns on inflammatory markers, advanced glycation end products and lipids in subjects without type 2 diabetes: A randomised crossover study |
Author: | Kim, Y. Keogh, J.B. Clifton, P.M. |
Citation: | Nutrients, 2017; 9(4):336-1-336-11 |
Publisher: | MDPI AG |
Issue Date: | 2017 |
ISSN: | 2072-6643 2072-6643 |
Statement of Responsibility: | Yoona Kim, Jennifer B. Keogh and Peter M. Clifton |
Abstract: | Epidemiological studies suggest that consumption of red and processed meat and refined grains are associated with type 2 diabetes and metabolic syndrome and increased inflammatory and fibrinolytic markers. We hypothesised that a diet high in red and processed meat and refined grains (HMD) would increase inflammatory markers and advanced glycation end products (AGEs) compared with a diet high in dairy, whole grains, nuts and legumes (HWD). We performed a randomised crossover study of two four-week interventions in 51 participants without type 2 diabetes (15 men and 36 women aged 35.1 ± 15.6 years; body mass index: 27.7 ± 6.9 kg/m²). No baseline measurements were performed. Plasma fluorescent AGEs, carboxymethyllysine, glucose, insulin, lipids, hs-CRP, interleukin 6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1) were analysed after four weeks on each diet. IL-6, hs-CRP, AGEs and carboxymethyllysine were not different between diets but PAI-1 was higher after the HMD than after HWD ((median and interquartile range) 158, 81 vs. 121, 53 ng/mL p < 0.001). PAI-1 on the HWD diet was inversely correlated with whole grains intake (p = 0.007). PAI-1 was inversely correlated with insulin sensitivity index (r = -0.45; p = 0.001) and positively correlated with serum total cholesterol (r = 0.35; p = 0.012) and serum triglyceride (r = 0.32; p = 0.021) on HMD. This trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12614000519651). |
Keywords: | dietary pattern; plasminogen activator inhibitor type 1; advanced glycation products; insulin sensitivity |
Description: | Published: 29 March 2017 |
Rights: | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/nu9040336 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.3390/nu9040336 |
Appears in Collections: | Molecular and Biomedical Science publications |
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hdl_138433.pdf | Published version | 234.07 kB | Adobe PDF | View/Open |
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