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https://hdl.handle.net/2440/140016
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dc.contributor.author | Liu, J. | - |
dc.contributor.author | Lee, J.Y.T. | - |
dc.contributor.author | Bedrikovetski, S. | - |
dc.contributor.author | Traeger, L. | - |
dc.contributor.author | Moore, J.W. | - |
dc.contributor.author | Perry, J.L. | - |
dc.contributor.author | Kroon, H.M. | - |
dc.contributor.author | Sammour, T. | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | European Journal of Surgical Oncology, 2023; 49(11):107070-1-107070-5 | - |
dc.identifier.issn | 0748-7983 | - |
dc.identifier.issn | 1532-2157 | - |
dc.identifier.uri | https://hdl.handle.net/2440/140016 | - |
dc.description | Available online 9 September 2023 | - |
dc.description.abstract | Pathological complete response (pCR) is observed in 11–26% of locally advanced rectal cancers undergoing neoadjuvant chemoradiotherapy (nCRT). This study aims to determine pCR rates and clinicopathological predictors in the Australian and New Zealand (ANZ) cohort. The Bi-National Colorectal Cancer Audit (BCCA) was interrogated for all rectal cancer patients who underwent nCRT prior to surgical resection between 2007 and 2020. Patients were divided in two groups: pCR (AJCC tumour regression grade 0) and partial/no response (pPR, regression grade 1,2 or 3). In total, 3230 patients were included. Rates of pCR and pPR were 704 (21.8%) and 2526 (78.2%), respectively. Long-course nCRT (p < 0.0001), lower clinical tumour stage (cT; p < 0.0001), and nodal stage (cN; p = 0.003) were associated with pCR on univariate analysis. On multivariable analysis, cN0 stage and long-course nCRT remained independent factors for a pCR. Awareness of these predictors provides valuable information when counseling patients regarding prognosis and treatment options. | - |
dc.description.statementofresponsibility | Jianliang Liu, Justin Y.T. Lee, Sergei Bedrikovetski, Luke Traeger, James W. Moore, Joanne L. Perry, Hidde M. Kroon, Tarik Sammour | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | Crown Copyright © 2023 Published by Elsevier Ltd. All rights reserved. | - |
dc.source.uri | https://www.sciencedirect.com/science/article/pii/S0748798323007084 | - |
dc.subject | Rectal cancer; Response; Tumour regression grade; Neoadjuvant therapy; Chemoradiotherapy | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Rectal Neoplasms | - |
dc.subject.mesh | Neoplasm Staging | - |
dc.subject.mesh | Treatment Outcome | - |
dc.subject.mesh | Neoadjuvant Therapy | - |
dc.subject.mesh | Retrospective Studies | - |
dc.subject.mesh | Australia | - |
dc.subject.mesh | New Zealand | - |
dc.subject.mesh | Chemoradiotherapy | - |
dc.title | Clinical predictors of rectal cancer response after neo-adjuvant (Chemo)Radiotherapy in Australia and New Zealand: Analysis of the Bi-National Colorectal Cancer Audit (BCCA) | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.ejso.2023.107070 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Liu, J. [0000-0001-5520-2011] | - |
dc.identifier.orcid | Bedrikovetski, S. [0000-0001-9330-625X] | - |
dc.identifier.orcid | Traeger, L. [0000-0002-0327-7334] | - |
dc.identifier.orcid | Kroon, H.M. [0000-0002-8923-7527] | - |
dc.identifier.orcid | Sammour, T. [0000-0002-4918-8871] | - |
Appears in Collections: | Surgery publications |
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