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https://hdl.handle.net/2440/140049
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Type: | Journal article |
Title: | The impact of acetylcholinesterase inhibitors on ileus and gut motility following abdominal surgery: a clinical review |
Author: | Traeger, L. Kroon, H.M. Bedrikovetski, S. Moore, J.W. Sammour, T. |
Citation: | ANZ Journal of Surgery, 2022; 92(1-2):69-76 |
Publisher: | Wiley |
Issue Date: | 2022 |
ISSN: | 1445-1433 1445-2197 |
Statement of Responsibility: | Luke Traeger, Hidde M. Kroon, Sergei Bedrikovetski, James W. Moore, and Tarik Sammour |
Abstract: | Postoperative ileus is a common complication in the days following colorectal surgery occurring in up to 50% of patients. When prolonged, this complication results in significant morbidity and mortality, doubling the total costs of hospital stay. Postoperative ileus (POI) results from the prolonged inflammatory phase that is mediated in part by the cholinergic anti-inflammatory pathway. Acetylcholinesterase inhibitors, such as neostigmine and pyridostigmine, delay the degradation of acetylcholine at the synaptic cleft. This increase in acetylcholine has been shown to increase gut motility. They have been effective in the treatment of acute colonic pseudo-obstruction, but there is limited evidence for the use of these medications for reducing the incidence of POI. This review was conducted to summarise the evidence of acetylcholinesterase inhibitors’ effect on gut motility and discuss their potential use as part of an enhanced recovery protocols to prevent or treat POI. |
Keywords: | colorectal surgery; ileus; neostigmine; pyridostigmine |
Rights: | © 2021 Royal Australasian College of Surgeons. |
DOI: | 10.1111/ans.17418 |
Published version: | http://dx.doi.org/10.1111/ans.17418 |
Appears in Collections: | Medicine publications |
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