Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/140271
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Type: | Journal article |
Title: | Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan |
Author: | Hollis, B. Day, F.R. Busch, A.S. Thompson, D.J. Soares, A.L.G. Timmers, P.R.H.J. Kwong, A. Easton, D.F. Joshi, P.K. Timpson, N.J. The PRACTICAL Consortium, 23andMe Research Team, Ong, K.K. Perry, J.R.B. Eeles, R.A. Henderson, B.E. Haiman, C.A. Kote-Jarai, Z. Schumacher, F.R. Olama, A.A.A. et al. |
Citation: | Nature Communications, 2020; 11(1):1536-1-1536-10 |
Publisher: | Springer Nature |
Issue Date: | 2020 |
ISSN: | 2041-1723 2041-1723 |
Statement of Responsibility: | Ben Hollis, Felix R. Day, Alexander S. Busch, Deborah J. Thompson, Ana Luiza G. Soares, Paul R.H.J. Timmers, Alex Kwong, Doug F. Easton, Peter K. Joshi, Nicholas J. Timpson, The PRACTICAL Consortium, 23andMe Research Team, Ken K. Ong and John R.B. Perry. Australian Prostate Cancer BioResource (APCB): Wayne Tilley ... Lisa Butler ... Pamela Saunders ... et al. |
Abstract: | The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes. |
Keywords: | 23andMe Research Team PRACTICAL Consortium Australian Prostate Cancer BioResource (APCB) |
Description: | Published online: 24 March 2020 |
Rights: | © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
DOI: | 10.1038/s41467-020-14451-5 |
Published version: | http://dx.doi.org/10.1038/s41467-020-14451-5 |
Appears in Collections: | Medicine publications |
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