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https://hdl.handle.net/2440/140528
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Type: | Journal article |
Title: | Particle-Based Artificial Antigen-Presenting Cell Systems for T Cell Activation in Adoptive T Cell Therapy |
Author: | Hou, F. Guo, Z. Ho, M.T. Hui, Y. Zhao, C.-X. |
Citation: | ACS Nano, 2024; 18(12):8571-8599 |
Publisher: | American Chemical Society (ACS) |
Issue Date: | 2024 |
ISSN: | 1936-0851 1936-086X |
Statement of Responsibility: | Fei Hou, Zichao Guo, Minh Trang Ho, Yue Hui, and Chun-Xia Zhao |
Abstract: | T cell-based adoptive cell therapy (ACT) has emerged as a promising treatment for various diseases, particularly cancers. Unlike other immunotherapy modalities, ACT involves directly transferring engineered T cells into patients to eradicate diseased cells; hence, it necessitates methods for effectively activating and expanding T cells in vitro. Artificial antigen-presenting cells (aAPCs) have been widely developed based on biomaterials, particularly micro- and nanoparticles, and functionalized with T cell stimulatory antibodies to closely mimic the natural T cell-APC interactions. Due to their vast clinical utility, aAPCs have been employed as an off-the-shelf technology for T cell activation in FDA-approved ACTs, and the development of aAPCs is constantly advancing with the emergence of aAPCs with more sophisticated designs and additional functionalities. Here, we review the recent advancements in particle-based aAPCs for T cell activation in ACTs. Following a brief introduction, we first describe the manufacturing processes of ACT products. Next, the design and synthetic strategies for micro- and nanoparticle-based aAPCs are discussed separately to emphasize their features, advantages, and limitations. Then, the impact of design parameters of aAPCs, such as size, shape, ligand density/mobility, and stiffness, on their functionality and biomedical performance is explored to provide deeper insights into the design concepts and principles for more efficient and safer aAPCs. The review concludes by discussing current challenges and proposing future perspectives for the development of more advanced aAPCs. |
Keywords: | adoptive cell therapy artificial antigen-presenting-cell CAR-T therapy microparticle nanoparticle particle size stiffness T cell activation T cell expansion |
Rights: | © 2024 American Chemical Society |
DOI: | 10.1021/acsnano.3c10180 |
Grant ID: | http://purl.org/au-research/grants/arc/DP20129314 http://purl.org/au-research/grants/nhmrc/2026797 http://purl.org/au-research/grants/nhmrc/2008698 |
Published version: | http://dx.doi.org/10.1021/acsnano.3c10180 |
Appears in Collections: | Research Outputs |
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