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https://hdl.handle.net/2440/16711
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Type: | Journal article |
Title: | Multidisciplinary management of head and neck sarcomas |
Author: | Colville, R. Charlton, F. Kelly, C. Nicoll, J. McLean, N. |
Citation: | Head and Neck: journal for the sciences and specialities of the head and neck, 2005; 27(9):814-824 |
Publisher: | John Wiley & Sons Inc |
Issue Date: | 2005 |
ISSN: | 1043-3074 1097-0347 |
Abstract: | <h4>Background</h4>Head and neck sarcomas are extremely rare. This article reviews the management and outcomes in a multidisciplinary clinic.<h4>Methods</h4>The records of 41 male and 19 female patients (mean age, 50 years) were reviewed. Forty percent underwent surgical resection only, 35% underwent surgery and adjuvant therapy, and 25% underwent radiotherapy and/or chemotherapy without surgery. Seventy-one percent had complete histologic clearance.<h4>Results</h4>The mean follow-up was 3 years and 10 months, with an overall 5-year survival rate of 60%. Completeness of surgical excision was highly significant in determining 5-year local control (p < .025), and the addition of adjuvant radiotherapy had a major effect on local control, but only if complete surgical clearance had been achieved (p < .025). As expected, patients with more aggressive tumors had a significantly poorer overall prognosis, and achieving local control led to an enhanced 5-year survival (p < .025).<h4>Conclusion</h4>These tumors are best managed in multidisciplinary clinics, and the mainstay of treatment is wide local excision and planned postoperative adjuvant radiotherapy. |
Keywords: | Humans Sarcoma Head and Neck Neoplasms Neoplasm Recurrence, Local Chemotherapy, Adjuvant Radiotherapy, Adjuvant Survival Rate Retrospective Studies Follow-Up Studies Adolescent Adult Aged Aged, 80 and over Middle Aged Child Child, Preschool Infant Patient Care Team Female Male United Kingdom |
DOI: | 10.1002/hed.20232 |
Published version: | http://dx.doi.org/10.1002/hed.20232 |
Appears in Collections: | Aurora harvest 6 Surgery publications |
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