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https://hdl.handle.net/2440/17154
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Type: | Journal article |
Title: | Topography of c-fos immunoreactivity in an ovine head impact model |
Author: | Finnie, J. Manavis, J. Jones, N. Blumbergs, P. |
Citation: | Journal of Clinical Neuroscience, 2005; 12(7):799-803 |
Publisher: | Churchill Livingstone |
Issue Date: | 2005 |
ISSN: | 0967-5868 1532-2653 |
Abstract: | Cortical neuronal and glial c-fos immunoreactivity has been demonstrated in experimental and human brain injury. c-fos is one of the immediate early genes important in signal transduction linking environmental stimuli to the cellular genome. c-fos immunoreactivity was semi-quantitated in a head impact sheep model using a grid system applied to standard coronal brain sections obtained from 12 impacted and 4 control sheep. Substantial glial and neuronal c-fos immunoreactivity was present in the pericontusional (penumbra) region, but was absent or minimal in the core of the contusion. Apart from these focal changes, c-fos immunoreactivity was diffusely distributed, with greater involvement in the cerebrum on the side of impact. In the cerebellum, Bergmann glia showed prominent c-fos immunoreactivity, while Purkinje cells were consistently immunonegative. c-fos immunoreactivity varied in different regions of the brain (focal and diffuse patterns) in this ovine head impact model. |
Keywords: | Temporal Lobe Animals Sheep Brain Injuries Disease Models, Animal Proto-Oncogene Proteins c-fos Immunohistochemistry Time Factors |
DOI: | 10.1016/j.jocn.2005.02.004 |
Published version: | http://dx.doi.org/10.1016/j.jocn.2005.02.004 |
Appears in Collections: | Aurora harvest 6 Pathology publications |
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