Adelaide Research & Scholarship
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https://hdl.handle.net/2440/22733
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| Type: | Journal article |
| Title: | Synthesis and biological activity of allosteric modulators of GABA(B) receptors, Part 2. 3-(2,6-bis-tert-butyl-4-hydroxyphenyl)propanols |
| Author: | Kerr, D. Khalafy, J. Ong, J. Perkins, M. Prager, R. Puspawati, N. Rimaz, M. |
| Citation: | Australian Journal of Chemistry: an international journal for chemical science, 2006; 59(7):457-462 |
| Publisher: | C S I R O Publishing |
| Issue Date: | 2006 |
| ISSN: | 0004-9425 |
| Statement of Responsibility: | David I. B. Kerr, Jabbar Khalafy, Jennifer Ong, Michael V. Perkins, Rolf H. Prager, Ni Made Puspawati and Mehdi Rimaz |
| Abstract: | A series of 13 2,2-disubstituted 3-(3,5-di-t-butyl-4-hydroxyphenyl)propan-1-ol derivatives have been prepared for evaluation as allosteric modulators of GABAB receptors. The activity (EC50, 4–7 μM) was greatest for the cyclohexyl and cyclopentyl analogues. |
| Rights: | © CSIRO 2006 |
| DOI: | 10.1071/CH06164 |
| Published version: | http://dx.doi.org/10.1071/ch06164 |
| Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 6 |
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