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https://hdl.handle.net/2440/23982
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Type: | Journal article |
Title: | Dose-dependent inhibition of the post-prandial glycaemic response to a standard carbohydrate meal following incorporation of alpha-cyclodextrin |
Author: | Buckley, J. Thorp, A. Murphy, K. Howe, P. |
Citation: | Annales Nestle, 2006; 50(2):108-114 |
Publisher: | Karger |
Issue Date: | 2006 |
ISSN: | 0250-6807 1421-9697 |
Abstract: | <h4>Background</h4>This study evaluated the dose-response effects of alpha-cyclodextrin, a cyclic oligosaccharide, on the glycaemic and insulinaemic responses to the consumption of a standard carbohydrate meal.<h4>Methods</h4>In a double-blind, randomised, cross-over design, 10 healthy subjects consumed boiled white rice containing 50 g of digestible carbohydrate to which 0 (control), 2, 5 or 10 g of alpha-cyclodextrin was added. Plasma glucose and insulin concentrations were determined prior to and for 2 h after consumption of each meal.<h4>Results</h4>The area under the plasma glucose curve was negatively related to the dose of alpha-cyclodextrin (r(2)=0.97, p=0.02), with the areas being significantly reduced at the 5- and 10-gram doses compared with the control (p<0.05). alpha-Cyclodextrin did not affect the area under the plasma insulin curve (p=0.39). Higher doses of alpha-cyclodextrin resulted in greater satiety, but were associated with reduced palatability and an increased incidence of minor gastrointestinal complaints (stomach ache, nausea, bloating).<h4>Conclusion</h4>alpha-Cyclodextrin reduces the glycaemic response to a standard carbohydrate meal in a dose-dependent manner and may be useful as an ingredient for reducing the glycaemic impact of such foods. |
Keywords: | Humans alpha-Cyclodextrins Insulin Dietary Carbohydrates Blood Glucose Area Under Curve Cross-Over Studies Double-Blind Method Satiety Response Taste Glycemic Index Postprandial Period Dose-Response Relationship, Drug Adult Female Male |
DOI: | 10.1159/000090498 |
Published version: | http://dx.doi.org/10.1159/000090498 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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