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https://hdl.handle.net/2440/27588
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dc.contributor.author | McColl, S. | - |
dc.contributor.author | St-Onge, M. | - |
dc.contributor.author | Dussault, A. | - |
dc.contributor.author | Laflamme, C. | - |
dc.contributor.author | Bouchard, L. | - |
dc.contributor.author | Boulanger, J. | - |
dc.contributor.author | Pouliot, M. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | The FASEB Journal, 2005; 19(13):U773-U791 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.issn | 1530-6860 | - |
dc.identifier.uri | http://hdl.handle.net/2440/27588 | - |
dc.description.abstract | In LPS-stimulated human neutrophils, engagement of the adenosine A2A receptor selectively prevented the expression and release of TNF-α, MIP-1α/CCL3, MIP-1β/CCL4, MIP-2α/CXCL2, and MIP-3α/CCL20. In mice lacking the A2A receptor, granulocytes that migrated into the air pouch 4 h after LPS injection expressed higher mRNA levels of TNF-α, MIP-1α, and MIP-1β than PMNs from wild-type mice. In mononuclear cells present in the air pouch 72 h after LPS injection, expression of IL-1β, TNF-α, IL-6, and MCP-2/CCL6 was higher in A2AR knockout mice. In addition to highlighting neutrophils as an early and pivotal target for mediating adenosine anti-inflammatory activities, these results identify TNF-α and the MIP chemokine family as gene products whose expression is pivotally affected by activation of A2AR in LPS-activated PMNs. Modulation by A2AR in the production of inflammatory signals by PMNs may thus influence the evolution of an inflammatory response by reducing the activation status of inflammatory cells. | - |
dc.description.statementofresponsibility | Shaun R. McColl, Mireille St-Onge, Andree-Anne Dussault, Cynthia Laflamme, Line Bouchard, Jean Boulanger, and Marc Pouliot | - |
dc.language.iso | en | - |
dc.publisher | Federation Amer Soc Exp Biol | - |
dc.rights | © 2005 FASEB | - |
dc.source.uri | http://www.fasebj.org/cgi/content/abstract/05-4804fjev1 | - |
dc.subject | polymorphonuclear leukocytes | - |
dc.subject | experimental animal models | - |
dc.subject | resolution of inflammation | - |
dc.title | Immunomodulatory impact of the A2A adenosine receptor on the profile of chemokines produced by neutrophils | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1096/fj.05-4804fje | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McColl, S. [0000-0003-0949-4660] | - |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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