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https://hdl.handle.net/2440/28097
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Type: | Journal article |
Title: | Carbon catabolite repression in Aspergillus nidulans involves deubiquitination |
Author: | Lockington, R. Kelly, J. |
Citation: | Molecular Microbiology, 2001; 40(6):1311-1321 |
Publisher: | Blackwell Science Ltd |
Issue Date: | 2001 |
ISSN: | 0950-382X 1365-2958 |
Statement of Responsibility: | Robin A. Lockington and Joan M. Kelly |
Abstract: | The best studied role of ubiquitination is to mark proteins for destruction by the proteasome but, in addition, it has recently been shown to promote macromolecular assembly and function, and alter protein function, thus playing a regulatory role distinct from protein degradation. Deubiquinating enzymes, the ubiquitin-processing proteases (ubps) and the ubiquitin carboxy-terminal hydrolases (uchs), remove ubiquitin from ubiquitinated substrates. We show here that the creB gene involved in carbon catabolite repression in Aspergillus nidulans encodes a functional member of the novel subfamily of the ubp family defined by the human homologue UBH1, thus implicating ubiquitination in the process of carbon catabolite repression. Members of the novel subfamily of ubps that include CreB are widespread amongst eukaryotes, with homologues present in mammals, nematodes, Drosophila and Arabidopsis, but mutations in the genes have only been identified in A. nidulans. From phenotypes of the A. nidulans mutants it is probable that this subfamily is involved in complex regulatory pathways. Mutations in the gene encoding the WD40 repeat protein CreC result in an identical phenotype, implicating both genes in this pathway. |
Keywords: | Aspergillus nidulans Carbon Protein Kinases Fungal Proteins Repressor Proteins Ubiquitins Cloning, Molecular Suppression, Genetic Amino Acid Sequence Base Sequence Conserved Sequence Mutation Molecular Sequence Data Cyclic AMP Response Element-Binding Protein |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1046/j.1365-2958.2001.02474.x |
Published version: | http://dx.doi.org/10.1046/j.1365-2958.2001.02474.x |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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