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https://hdl.handle.net/2440/28121
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Type: | Journal article |
Title: | Fragile and unstable chromosomes in cancer: causes and consequences |
Author: | Richards, R. |
Citation: | Trends in Genetics, 2001; 17(6):339-345 |
Publisher: | Elsevier Science London |
Issue Date: | 2001 |
ISSN: | 0168-9525 |
Abstract: | Cancer cells commonly exhibit various forms of genetic instability, such as changes in chromosome copy number, translocations and point mutations in particular genes. Although transmissible change seems to be an essential part of the neoplastic process, the extent to which DNA instability is a cause rather than a consequence of cancer is unclear. Chromosomal fragile sites have been proposed to be not only susceptible to DNA instability in cancer cells, but also associated with genes that contribute to the neoplastic process. Mutation at fragile site loci might therefore have a causative role in cancer. Recent studies on one class of human chromosomal fragile sites show that instability at fragile site loci can functionally contribute to tumor cell biology. |
Keywords: | Chromosomes, Human Animals Humans Neoplasms Cell Transformation, Neoplastic Chromosome Fragility Chromosome Mapping Mutation Chromosome Fragile Sites |
DOI: | 10.1016/S0168-9525(01)02303-4 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/405918/description#description |
Published version: | http://dx.doi.org/10.1016/s0168-9525(01)02303-4 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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