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https://hdl.handle.net/2440/28174
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dc.contributor.author | Turnidge, J. | - |
dc.contributor.author | Bell, J. | - |
dc.contributor.author | Biedenbach, D. | - |
dc.contributor.author | Jones, R. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | International Journal of Antimicrobial Agents, 2002; 20(1):10-17 | - |
dc.identifier.issn | 0924-8579 | - |
dc.identifier.issn | 1872-7913 | - |
dc.identifier.uri | http://hdl.handle.net/2440/28174 | - |
dc.description | Copyright © 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved. | - |
dc.description.abstract | Worldwide surveillance of antimicrobial resistance among urinary tract pathogens is useful to determine important trends and geographical variation for common Gram-positive and -negative species. The most common causative uropathogens often have intrinsic or acquired resistance mechanisms which include ESBL production among enteric bacilli, multi-drug resistant staphylococci and non-fermentative Gram-negative bacilli such as Pseudomonas aeruginosa and Acinetobacter spp. and vancomycin-resistant Enterococcus spp. This study evaluates pathogen frequency and the resistance rates among urinary tract infection (UTI) pathogens in 14 medical centres in the Asia-Pacific region between 1998 and 1999. The isolates were referred to a central monitor for reference NCCLS broth microdilution testing, identification confirmation and patient demographic analysis. Over 50% of the 958 pathogens were Escherichia coli and Klebsiella spp. followed by P. aeruginosa, Enterococcus spp. and Enterobacter spp. Susceptibility for the three enteric bacilli was high for carbapenems (100%), 'fourth-generation' cephalosporins (cefepime 94.9-98.6%) and amikacin (> or = 93.0%). Beta-lactamase inhibitor compounds were more active against E. coli (piperacillin/tazobactam; > 90% susceptible) than the other two enteric species and all other tested agents had a narrower spectra of activity. The rank order of anti-pseudomonal agents was amikacin (91.5% susceptible)> imipenem > piperacillin/tazobactam > tobramycin > ceftazidime and cefepime (77.4 and 76.4% susceptible, respectively). Susceptibility to quinolones for the P. aeruginosa isolates was only 63.2-67.0%. Only one vancomycin-intermediate Enterococcus spp. (van C phenotype) was detected among the 103 strains tested. Newer fluoroquinolones (gatifloxacin; MIC(50), mg/l) were more potent against enterococci than ciprofloxacin (MIC(50), 2 mg/l) and high-level resistance to aminoglycosides was common (41.7%). The data presented are compared to studies of similar design from other areas which are part of the SENTRY surveillance network. | - |
dc.description.statementofresponsibility | John Turnidge, Jan Bell, Douglas J. Biedenbach and Ronald N. Jones | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/505521/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science BV | - |
dc.source.uri | http://dx.doi.org/10.1016/s0924-8579(02)00050-x | - |
dc.subject | Humans | - |
dc.subject | Gram-Negative Bacteria | - |
dc.subject | Gram-Positive Bacteria | - |
dc.subject | Urinary Tract Infections | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Microbial Sensitivity Tests | - |
dc.subject | Drug Resistance, Microbial | - |
dc.subject | North America | - |
dc.subject | Asia | - |
dc.subject | Female | - |
dc.subject | Global Health | - |
dc.title | Pathogen occurrence and antimicrobial resistance trends among urinary tract infection isolates in the Asia-Western Pacific Region: report from the SENTRY Antimicrobial Surveillance Program, 1998-1999 | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0924-8579(02)00050-X | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Turnidge, J. [0000-0003-4240-5578] | - |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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