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https://hdl.handle.net/2440/2915
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dc.contributor.author | Farnsworth, E. | - |
dc.contributor.author | Luscombe-Marsh, N. | - |
dc.contributor.author | Noakes, M. | - |
dc.contributor.author | Wittert, G. | - |
dc.contributor.author | Argyiou, E. | - |
dc.contributor.author | Clifton, P. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | American Journal of Clinical Nutrition, 2003; 78(1):31-39 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.issn | 1938-3207 | - |
dc.identifier.uri | http://hdl.handle.net/2440/2915 | - |
dc.description | Copyright © 2003 American Society for Clinical Nutrition | - |
dc.description.abstract | <h4>Background</h4>It is not clear whether varying the protein-to-carbohydrate ratio of weight-loss diets benefits body composition or metabolism.<h4>Objective</h4>The objective was to compare the effects of 2 weight-loss diets differing in protein-to-carbohydrate ratio on body composition, glucose and lipid metabolism, and markers of bone turnover.<h4>Design</h4>A parallel design included either a high-protein diet of meat, poultry, and dairy foods (HP diet: 27% of energy as protein, 44% as carbohydrate, and 29% as fat) or a standard-protein diet low in those foods (SP diet: 16% of energy as protein, 57% as carbohydrate, and 27% as fat) during 12 wk of energy restriction (6-6.3 MJ/d) and 4 wk of energy balance ( approximately 8.2 MJ/d). Fifty-seven overweight volunteers with fasting insulin concentrations > 12 mU/L completed the study.<h4>Results</h4>Weight loss (7.9 +/- 0.5 kg) and total fat loss (6.9 +/- 0.4 kg) did not differ between diet groups. In women, total lean mass was significantly (P = 0.02) better preserved with the HP diet (-0.1 +/- 0.3 kg) than with the SP diet (-1.5 +/- 0.3 kg). Those fed the HP diet had significantly (P < 0.03) less glycemic response at weeks 0 and 16 than did those fed the SP diet. After weight loss, the glycemic response decreased significantly (P < 0.05) more in the HP diet group. The reduction in serum triacylglycerol concentrations was significantly (P < 0.05) greater in the HP diet group (23%) than in the SP diet group (10%). Markers of bone turnover, calcium excretion, and systolic blood pressure were unchanged.<h4>Conclusion</h4>Replacing carbohydrate with protein from meat, poultry, and dairy foods has beneficial metabolic effects and no adverse effects on markers of bone turnover or calcium excretion. | - |
dc.description.statementofresponsibility | Emma Farnsworth, Natalie D Luscombe, Manny Noakes, Gary Wittert, Eleni Argyiou and Peter M Clifton | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Clinical Nutrition | - |
dc.source.uri | http://www.ajcn.org/cgi/content/abstract/78/1/31 | - |
dc.subject | Humans | - |
dc.subject | Hyperinsulinism | - |
dc.subject | Insulin Resistance | - |
dc.subject | Obesity | - |
dc.subject | Blood Glucose | - |
dc.subject | Lipids | - |
dc.subject | Fatty Acids, Nonesterified | - |
dc.subject | Triglycerides | - |
dc.subject | Dietary Proteins | - |
dc.subject | Diet | - |
dc.subject | Body Composition | - |
dc.subject | Energy Intake | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Cholesterol, LDL | - |
dc.subject | Cholesterol, HDL | - |
dc.title | Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/ajcn/78.1.31 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Luscombe-Marsh, N. [0000-0001-9690-4722] | - |
dc.identifier.orcid | Wittert, G. [0000-0001-6818-6065] | - |
dc.identifier.orcid | Clifton, P. [0000-0002-6411-626X] | - |
Appears in Collections: | Aurora harvest 6 Medicine publications Molecular and Biomedical Science publications |
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