Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/3005
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Boase, N. | - |
dc.contributor.author | Lockington, R. | - |
dc.contributor.author | Adams, J. | - |
dc.contributor.author | Rodbourn, L. | - |
dc.contributor.author | Kelly, J. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Genetics: a periodical record of investigations bearing on heredity and variation, 2003; 164(1):95-104 | - |
dc.identifier.issn | 0016-6731 | - |
dc.identifier.issn | 1943-2631 | - |
dc.identifier.uri | http://hdl.handle.net/2440/3005 | - |
dc.description | Copyright © 2003 by the Genetics Society of America | - |
dc.description.abstract | Mutations in the acrB gene, which were originally selected through their resistance to acriflavine, also result in reduced growth on a range of sole carbon sources, including fructose, cellobiose, raffinose, and starch, and reduced utilization of ω-amino acids, including GABA and ß-alanine, as sole carbon and nitrogen sources. The acrB2 mutation suppresses the phenotypic effects of mutations in the creB gene that encodes a regulatory deubiquitinating enzyme, and in the creC gene that encodes a WD40-repeat-containing protein. Thus AcrB interacts with a regulatory network controlling carbon source utilization that involves ubiquitination and deubiquitination. The acrB gene was cloned and physically analyzed, and it encodes a novel protein that contains three putative transmembrane domains and a coiled-coil region. AcrB may play a role in the ubiquitination aspect of this regulatory network. | - |
dc.description.statementofresponsibility | Natasha A. Boase, Robin A. Lockington, Julian R. J. Adams, Louise Rodbourn and Joan M. Kelly | - |
dc.language.iso | en | - |
dc.publisher | Genetics | - |
dc.source.uri | http://www.genetics.org/cgi/content/abstract/164/1/95 | - |
dc.subject | Aspergillus nidulans | - |
dc.subject | Acriflavine | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Base Sequence | - |
dc.subject | Mutation | - |
dc.subject | Molecular Sequence Data | - |
dc.title | Molecular characterization and analysis of the acrB gene of Aspergillus nidulans: A gene identified by genetic interaction as a component of the regulatory network that includes the CreB deubiquitination enzyme | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/genetics/164.1.95 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
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Boa_Mol_v164n12002.pdf | 286.35 kB | Publisher's PDF | View/Open |
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