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https://hdl.handle.net/2440/30498
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dc.contributor.author | Bathgate, R. | - |
dc.contributor.author | Ivell, R. | - |
dc.contributor.author | Sanborn, B. | - |
dc.contributor.author | Sherwood, O. | - |
dc.contributor.author | Summers, R. | - |
dc.contributor.editor | Sherwood, O. | - |
dc.contributor.editor | Fields, P. | - |
dc.contributor.editor | Steinetz, B. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Relaxin and related peptides, 2005 / Sherwood, O., Fields, P., Steinetz, B. (ed./s), vol.1041, pp.61-76 | - |
dc.identifier.isbn | 1573314854 | - |
dc.identifier.uri | http://hdl.handle.net/2440/30498 | - |
dc.description.abstract | Recent studies have identified four receptors that are the physiological targets for relaxin family peptides. All are class I (rhodopsin like) G-protein-coupled receptors with LGR7 (RXFP1) and LGR8 (RXFP2) being type C leucine-rich repeat-containing receptors, whereas GPCR135 (RXFP3) and GPCR142 (RXFP4) resemble receptors that respond to small peptides such as somatostatin and angiotensin II. The cognate ligands for the receptors have been identified: relaxin for RXFP1; INSL3 for RXFP2; relaxin 3 for RXFP3 and INSL5 for RXFP4. RXFP1 and RXFP2 receptors produce increases in intracellular cAMP levels upon stimulation, although the response is complex and contains a component sensitive to PI-3-kinase inhibitors. There is also evidence that RXFP1 can activate Erk1/2 and nitric oxide synthase, and relaxin has been reported to enter cells and activate glucocorticoid receptors. In contrast, RXFP3 and RXFP4 couple to Gi by a pertussis toxin-sensitive mechanism to cause inhibition of cAMP production. Now that the receptors for relaxin family peptides and their cognate ligands have been identified, we suggest a nomenclature for both the peptides and the receptors that we hope will be helpful to researchers in this rapidly advancing field. | - |
dc.language.iso | en | - |
dc.publisher | New York Academy of Sciences | - |
dc.relation.ispartofseries | Annals of the New York Academy of Sciences ; v. 1041 | - |
dc.source.uri | http://dx.doi.org/10.1196/annals.1282.010 | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Relaxin | - |
dc.subject | Receptors, G-Protein-Coupled | - |
dc.subject | Receptors, Peptide | - |
dc.subject | Ligands | - |
dc.subject | Signal Transduction | - |
dc.subject | Gene Expression | - |
dc.title | Receptors for relaxin family peptides | - |
dc.type | Book chapter | - |
dc.identifier.doi | 10.1196/annals.1282.010 | - |
dc.publisher.place | New York, USA | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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