Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/3102
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DC Field | Value | Language |
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dc.contributor.author | Smith, A. | - |
dc.contributor.author | Jackson, M. | - |
dc.contributor.author | Neufing, P. | - |
dc.contributor.author | McEvoy, R. | - |
dc.contributor.author | Gordon, T. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | The Lancet, 2004; 364(9451):2122-2124 | - |
dc.identifier.issn | 0140-6736 | - |
dc.identifier.issn | 1474-547X | - |
dc.identifier.uri | http://hdl.handle.net/2440/3102 | - |
dc.description.abstract | Narcolepsy is widely believed to have an autoimmune basis, but conventional immunological approaches have failed to detect a serum autoantibody marker. Since cholinergic hyperactivity is a feature of narcolepsy-cataplexy, we transferred IgG from nine patients with narcolepsy and nine healthy controls to mice and assessed the effect on smooth muscle contractile responses to cholinergic stimulation. IgG from all narcolepsy patients significantly enhanced bladder contractile responses to the muscarinic agonist carbachol and to neuronally released acetylcholine compared with control IgG (p<0.0001), whereas contraction of the sympathetically innervated vas deferens was unaltered. Our findings provide direct evidence for the autoimmune hypothesis of narcolepsy. | - |
dc.language.iso | en | - |
dc.publisher | Lancet Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/s0140-6736(04)17553-3 | - |
dc.subject | Muscle, Smooth | - |
dc.subject | Parasympathetic Nervous System | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred BALB C | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Narcolepsy | - |
dc.subject | Carbachol | - |
dc.subject | Immunoglobulin G | - |
dc.subject | Membrane Glycoproteins | - |
dc.subject | Cholinergic Agonists | - |
dc.subject | Autoantibodies | - |
dc.subject | HLA-DQ Antigens | - |
dc.subject | Synaptic Transmission | - |
dc.subject | Muscle Contraction | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | HLA-DQ beta-Chains | - |
dc.subject | In Vitro Techniques | - |
dc.title | A functional autoantibody in narcolepsy | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0140-6736(04)17553-3 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McEvoy, R. [0000-0002-5759-0094] | - |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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