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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/3132
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dc.contributor.authorTan, N.-
dc.contributor.authorHeron, S.-
dc.contributor.authorScheffer, I.-
dc.contributor.authorPelekanos, J.-
dc.contributor.authorMcMahon, J.-
dc.contributor.authorVears, D.-
dc.contributor.authorMulley, J.-
dc.contributor.authorBerkovic, S.-
dc.date.issued2004-
dc.identifier.citationNeurology, 2004; 63(6):1090-1092-
dc.identifier.issn0028-3878-
dc.identifier.issn1526-632X-
dc.identifier.urihttp://hdl.handle.net/2440/3132-
dc.descriptionCopyright © 2004 American Academy of Neurology-
dc.description.abstractAlteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.-
dc.description.urihttp://www.neurology.org/cgi/content/abstract/63/6/1090-
dc.language.isoen-
dc.publisherLippincott Williams & Wilkins-
dc.source.urihttp://dx.doi.org/10.1212/01.wnl.0000137051.33486.c7-
dc.subjectHippocampus-
dc.subjectEpilepsy, Temporal Lobe-
dc.subjectSclerosis-
dc.subjectAnticonvulsants-
dc.subjectReproducibility of Results-
dc.subjectAmino Acid Substitution-
dc.subjectDrug Resistance, Multiple-
dc.subjectGene Frequency-
dc.subjectGenotype-
dc.subjectHaplotypes-
dc.subjectMutation, Missense-
dc.subjectPolymorphism, Genetic-
dc.subjectPolymorphism, Single Nucleotide-
dc.subjectAlleles-
dc.subjectExons-
dc.subjectVictoria-
dc.subjectATP Binding Cassette Transporter, Subfamily B, Member 1-
dc.titleFailure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy-
dc.typeJournal article-
dc.identifier.doi10.1212/01.WNL.0000137051.33486.C7-
pubs.publication-statusPublished-
dc.identifier.orcidHeron, S. [0000-0001-8759-6748]-
Appears in Collections:Aurora harvest 6
Molecular and Biomedical Science publications

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